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845 articles
June 202619
A fatal case of Legionella micdadei prosthetic valve endocarditis diagnosed by plasma microbial cell-free DNA metagenomic sequencing.
An immunocompromised patient developed an indolent outpatient illness that progressed rapidly to mixed shock. Evaluation revealed prosthetic valve endocarditis complicated by valve dehiscence and sepsis.
Keratoameloblastoma of the Jaw Bones: Description of 2 Rare Cases and Cytokeratin Profile.
Two adult men had keratoameloblastomas involving the jaw bones. Histology showed fibrous stroma containing keratinizing follicular cysts with central parakeratin plugs, combining features resembling ameloblastoma and…
A Stomach Neuroendocrine Carcinoma With CCNE1 Amplification: A Case Report and Brief Review of Literature.
The report describes a patient with a gastric neuroendocrine carcinoma whose morphology and molecular alterations were ambiguous, raising the diagnostic challenge of distinguishing poorly differentiated neuroendocrine…
Suspected thermal amplitude of cryoglobulin likely more clinically significant than size detected: A case report.
A patient with known lymphoplasmacytic lymphoma developed extensive necrosis of the fingers and toes. Testing detected a small type I cryoglobulin, but its significance was uncertain.
Congenital myasthenic syndrome due to novel GFPT1 variant presenting with head drop and visual impairment: A case report.
A 5-year-old boy had hypotonia, progressive weakness with head drop, cognitive delay, and visual impairment. Neuroimaging showed white matter abnormalities and atrophy of the corpus callosum and cerebellum.
Underreporting of Interrater Agreement in Diagnostic Accuracy Studies of Immunohistochemistry in Dermatopathology: A Systematic Review.
This systematic review examined the reporting of interobserver agreement in diagnostic accuracy studies of immunohistochemistry (IHC) in dermatopathology, analyzing 84 studies published between 2015 and 2025.
Illegal electric fencing acting as a death trap in a suspected homicide.
A decomposed male body was found in a remote mountainous area, initially suspected to be a homicide. Autopsy and clothing examination revealed high-voltage electrical injuries, while the absence of an electrical source…
Pseudoangiomatous Stromal Hyperplasia-Like Change in Mixed Epithelial and Stromal Tumor of the Seminal Vesicle: A Case Report Expanding the Morphologic Spectrum With 19-Year Follow-Up.
A 70-year-old man had a low-grade mixed epithelial and stromal tumor (MEST) of the seminal vesicle. Needle biopsy showed interconnecting slit-like spaces in keloid-like collagen, lined by bland spindle cells and lacking…
The First Report of BRAF V600E Mutation in Paratesticular Mesothelioma.
A 44-year-old man with a history of asbestos exposure presented with painless right testicular swelling. Orchiectomy showed a 1.5-cm biphasic paratesticular mesothelioma, predominantly sarcomatoid (80%) with an…
Epstein-Barr virus-associated thymic lymphoepithelial carcinoma in a child.
A 12-year-old patient presented with a mediastinal mass, supraclavicular lymphadenopathy, and pulmonary metastases. Histology established Epstein-Barr virus (EBV)-positive thymic lymphoepithelial carcinoma.
Cystic Panfolliculoma of the Eyelid.
A woman in her early 90s had a painless, crateriform lesion at the left eyelid and lower eyebrow that had worsened over approximately 1 year, fluctuated in size, and sometimes shed a scab with drainage.
Histiocytic Sarcoma of the Eyelid: An Uncommon Presentation of a Rare Neoplasm.
An 80-year-old man presented with a rapidly enlarging lesion of the left lower eyelid over 4 months. Shave biopsy showed histologic and immunophenotypic features most consistent with morphologically low-grade…
Papillary-Predominant FLCN -Mutated Renal Epithelial Neoplasm in Birt-Hogg-Dubé Syndrome.
A 79-year-old woman with Birt-Hogg-Dubé syndrome and a pathogenic germline FLCN frameshift mutation presented with bilateral renal masses and underwent right partial nephrectomy.
Renal Pelvis Squamous Cell Carcinoma Arising in the Setting of Long-Standing Nephrolithiasis: Clinicopathologic and Molecular Insights.
Two patients with decades-long renal stone disease developed squamous cell carcinoma of the renal pelvis. Both tumors showed extensive squamous metaplasia, moderately differentiated carcinoma with comedo-type necrosis…
Recurrent Myopericytoma of the Breast Mimicking Phyllodes Tumour: A Diagnostic and Management Challenge.
A 37-year-old woman presented with a recurrent left breast mass whose clinical and radiological features suggested phyllodes tumour.
Clinically Silent Sjögren Syndrome Presenting With Cryoglobulinemia.
A 33-year-old woman presented with pedal edema, intermittent arthralgia, hematuria, and impaired renal function. Kidney biopsy showed intraluminal pseudothrombi with dominant immunoglobulin M deposition, consistent with…
Granulation Tissue-Like Spindle Cell Squamous Cell Carcinoma of the Skin Arising in a Burn Scar.
A 66-year-old woman presented with a clinically ulcerated 3.5 × 2.7 cm mass arising in an upper-arm burn scar. Punch biopsy showed a deceptively bland but atypical spindle-cell proliferation with focal slit-like…
Metaplastic-Like and Squamous Cell Carcinoma-Like Cells in Liquid-Based Cytology Associated With Small Cell Neuroendocrine Carcinoma of the Uterine Cervix.
Metaplastic-like cells exhibit an eccentric nucleus. SCC-like cells are planar aggregates with prominent atypical nuclei, similar to SCCs.
Nodular Fasciitis of the Parotid Gland Mimicking Pleomorphic Adenoma: Cytological Features of a Diagnostic Pitfall.
A 19-year-old female presented with a mass in the parotid gland, initially diagnosed as a salivary gland neoplasm via fine needle aspiration.
May 20265
Percc1-Associated Congenital Diarrhea and Enteropathy: Description of a Novel Variant.
An infant diagnosed at 2 months of age had congenital diarrhea and enteropathy associated with a novel homozygous PERCC1 variant, c.337 del, in exon 2.
Intramuscular myxoma with chondroid features: two cases expanding the morphological spectrum.
Two cases of intramuscular myxoma with chondroid features are presented. The first case involved a 64-year-old woman with a tumor in the triceps, exhibiting focal cartilaginous differentiation.
Tubulo-Squamous Vaginal Polyp: A Clinicopathologic Series with Literature Review.
The authors describe six tubulo-squamous polyps of the vagina identified in routine practice. These benign, upper-vaginal lesions occur in postmenopausal women.
Lethal Suspected DICER1 Syndrome Spectrum in Neonate with CPAM Type IV/Type I PPB, Genitourinary Abnormalities, and CNS Embryonal Tumor with Multilayered Rosettes.
A premature neonate, aged 8 days, had been diagnosed prenatally with renal and cystic lung abnormalities and died from severe respiratory dysfunction.
Low-risk HPV-associated invasive carcinoma with squamous and glandular features arising in a Buschke-Löwenstein tumour.
A 70-year-old woman underwent abdominoperineal resection for an anal mass associated with a perirectal abscess and rectovaginal fistula.
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