Keratoameloblastoma of the Jaw Bones: Description of 2 Rare Cases and Cytokeratin Profile.

Appl Immunohistochem Mol MorpholJun 8, 2026 (epub)
Case ReportPathology (Anatomic & Clinical)General Surgery

Felipe Barreto Lemos, Paulo Tambasco De Oliveira, Flávia Caló de Aquino Xavier et al.

✦ AI-curated · Sources linked

Case in brief

Two adult men had keratoameloblastomas involving the jaw bones. Histology showed fibrous stroma containing keratinizing follicular cysts with central parakeratin plugs, combining features resembling ameloblastoma and odontogenic keratocyst. Immunohistochemistry showed variable positivity for the cytokeratins studied, except CK8 and CK18, which were negative; the Ki-67 proliferation index was low. Both patients remained under follow-up without recurrence after 4 years.

What made this case unusual

The lesions combined ameloblastoma-like features with keratinizing cystic formations resembling an odontogenic keratocyst, creating a histopathologic overlap relevant to diagnosis.

Diagnostic / clinical pearl

Keratoameloblastoma can show both ameloblastoma-like and odontogenic keratocyst-like morphology; the reported cytokeratin profile was variable, with CK8 and CK18 negative.

Source

PubMed · PMID 42258606

Published in Appl Immunohistochem Mol Morphol. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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