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Important medical research and remarkable case reports worth knowing.

Selected from high-relevance medical literature published in the last 14 days.

AllClinical ResearchCase Reports
FeaturedClinical ResearchPreventive Medicine / Public Health

2025 National Guidelines on the Mediterranean Diet: Executive Summary of a Joint Report by Italian Scientific Societies and the National Institute of Health Task Force on Clinical Practice Guidelines.

Nutr RevNov 12, 2026

This systematic review and practice guideline, developed by a multidisciplinary panel using NUTRIGRADE, assessed Mediterranean diet evidence across nine health domains and one economic domain.

Why it matters

The guideline synthesizes evidence across multiple clinical and public health domains, indicating that dietary patterns may be relevant to prevention and outcomes across a broad range of non-communicable diseases.

Read summary

Also worth knowing

Clinical ResearchOrthopedic Surgery

Prevention of Venous Thromboembolism after Total Hip or Knee Replacement.

This multicenter randomized comparative-effectiveness noninferiority trial compared 30 days of aspirin, warfarin, or rivaroxaban for VTE prophylaxis after elective total hip or knee arthroplasty.

N Engl J MedNov 12, 2026Read summary
Clinical ResearchAnesthesiology

Effect of discontinuing antihypertensives on perioperative hypotension in older patients before non-cardiac surgery: multicentre, randomised, double blind, controlled trial.

This multicentre, randomised, double blind, placebo controlled trial assessed whether withholding ACE inhibitors or ARBs on the morning of surgery reduces perioperative hypotension in older adults undergoing non-cardiac…

BMJNov 11, 2026Read summary
Clinical ResearchNeurologyOpen access

Loberamisal for Acute Ischemic Stroke: The LAIS Randomized Clinical Trial.

The LAIS trial was a multicenter, double-blind, randomized, placebo-controlled phase 3 study at 32 hospitals in China. It enrolled adults aged 18 to 80 years with acute ischemic stroke, treated within 48 hours, and…

JAMANov 10, 2026Read summary
Clinical ResearchEndocrinology

Plozasiran for Severe Hypertriglyceridemia and Risk of Pancreatitis.

Two double-blind, placebo-controlled randomized trials evaluated plozasiran in 757 adults with severe hypertriglyceridemia.

N Engl J MedNov 5, 2026Read summary
Clinical ResearchAnesthesiology

Thoracic epidural versus paravertebral blockade for reducing chronic post-thoracotomy pain (TOPIC-2): open label, parallel group, superiority, multicentre, randomised controlled trial.

This open-label, multicentre, parallel-group superiority randomised trial compared perioperative paravertebral blockade with thoracic epidural in adults undergoing thoracotomy at 15 UK centres.

BMJNov 5, 2026Read summary
Clinical ResearchEndocrinology

Effects of Vitamin D Supplementation in Combination With Exercise Training on Body Composition and Muscular Strength in Adults: A Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials.

This systematic review and dose-response meta-analysis of randomized controlled trials assessed whether vitamin D supplementation added to exercise improves body composition or muscular strength compared with exercise…

Nutr RevNov 12, 2026Read summary
Clinical ResearchUrology

Exploring the Association Between Cannabis Use and Male Reproductive Parameters: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis examined associations between cannabis use and male reproductive parameters. It included 18 studies reporting sperm outcomes (5,766 patients; 6,231 samples) and hormonal outcomes…

Int Braz J UrolNov 12, 2026Read summary
Clinical ResearchOncology (Medical)

Poly (ADP-ribose) polymerase inhibitors (PARPi) for treating advanced epithelial ovarian cancer.

This Cochrane systematic review and meta-analysis assessed randomised trials of PARP inhibitors (PARPi) in women with newly diagnosed or recurrent epithelial ovarian cancer. It included 24 studies with 8961 participants.

Cochrane Database Syst RevNov 11, 2026Read summary
Clinical ResearchObstetrics & Gynecology

Regimens of vitamin D supplementation for women during pregnancy.

This updated Cochrane systematic review and meta-analysis assessed randomised trials of vitamin D regimens during pregnancy in women without pre-existing conditions or multiple pregnancies.

Cochrane Database Syst RevNov 11, 2026Read summary
Clinical ResearchNeurologyOpen access

Efficacy and safety of selective orexin 2 receptor agonists in narcolepsy type 1: a systematic review and meta-analysis of randomized controlled trials.

This systematic review and meta-analysis pooled randomized, double-blind, placebo-controlled trials of oral selective orexin 2 receptor agonists in people with narcolepsy type 1.

J NeurolNov 11, 2026Read summary
Clinical ResearchOncology (Medical)Open access

Postoperative Tumor-Informed Circulating Tumor DNA Status for Molecular Residual Disease Detection After Curative-Intent Resection of Pancreatic Ductal Adenocarcinoma: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis pooled observational evidence on postoperative tumor-informed circulating tumor DNA (ctDNA) as a marker of molecular residual disease after curative-intent resection of…

J Gastrointest CancerNov 11, 2026Read summary

Showing 12 of 400 publications that cleared our clinical screen in the last 14 days.

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