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Important medical research and remarkable case reports worth knowing.

Selected from high-relevance medical literature published in the last 14 days.

AllClinical ResearchCase Reports
FeaturedClinical ResearchOncology (Medical)

Postoperative Tumor-Informed Circulating Tumor DNA Status for Molecular Residual Disease Detection After Curative-Intent Resection of Pancreatic Ductal Adenocarcinoma: A Systematic Review and Meta-Analysis.

J Gastrointest CancerNov 11, 2026Open access

This systematic review and meta-analysis pooled observational evidence on postoperative tumor-informed circulating tumor DNA (ctDNA) as a marker of molecular residual disease after curative-intent resection of…

Why it matters

Postoperative recurrence is common in pancreatic ductal adenocarcinoma, while conventional imaging and CA19-9 have limited sensitivity for molecular residual disease.

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Also worth knowing

Clinical ResearchOncology (Medical)Open access

Survival Outcomes in Metastatic Colorectal Cancer Patients with BRAF Mutations Undergoing Targeted Chemotherapy: A Reconstructed Individual Patient Data Meta-Analysis of Randomized Controlled Trials.

This reconstructed individual patient-data meta-analysis of 18 randomized controlled trials examined survival outcomes across targeted treatment classes in BRAF V600E-mutant metastatic colorectal cancer.

J Gastrointest CancerOct 30, 2026Read summary
Clinical ResearchUrologyOpen access

Diagnostic yield and early outcomes of radical prostatectomy without prior histopathologic diagnosis: a single-arm systematic review and meta-analysis.

This single-arm systematic review and random-effects meta-analysis assessed radical prostatectomy without prior histopathologic confirmation in adult men with high clinical suspicion of clinically significant prostate…

World J UrolNov 10, 2026Read summary
Clinical ResearchGastroenterologyOpen access

Polyamine Dysregulation in Metabolic Dysfunction-associated Steatotic Liver Disease: a Systematic Review of Human Observational Evidence.

This systematic review evaluated human observational evidence linking polyamines with MASLD severity and related hepatic or metabolic outcomes.

Curr Obes RepNov 11, 2026Read summary
Clinical ResearchPathology (Anatomic & Clinical)

Curriculum-Aligned Conversational AI to Support Pathology Self-Directed Learning in Preclinical Medical Students: Crossover Randomized Pilot Study.

This crossover randomized pilot study evaluated a curriculum-aligned custom GPT for self-directed pathology learning among 44 second-year medical students at the University of South Carolina, Floyd School of Medicine.

JMIR Med EducNov 6, 2026Read summary
Clinical ResearchGastroenterology

Prognostic value of anti-gp210 antibodies in primary biliary cholangitis: A Systematic review and meta-analysis.

This systematic review and meta-analysis pooled evidence from 12 records examining the prognostic significance of anti-gp210 antibodies in people with primary biliary cholangitis (PBC).

Medicine (Baltimore)Nov 6, 2026Read summary
Clinical ResearchPathology (Anatomic & Clinical)Open access

Molecular Diagnostics and Clinicopathologic Spectrum of Kinase Fusion-Positive Spindle Cell Neoplasms of the Oral and Maxillofacial Region: A Systematic Review and Pooled Patient-Level Analysis.

This systematic review and pooled patient-level analysis characterized kinase fusion-positive spindle cell neoplasms of the oral and maxillofacial region using published reports.

Head Neck PatholNov 9, 2026Read summary
Clinical ResearchOncology (Medical)

Spatial Acid-Associated Niches Inform Irinotecan-Based DEB-TACE in Colorectal Liver Metastases: A Multicentre Randomized Trial.

This multicentre randomised trial combined transcriptomic and spatial analyses of colorectal liver metastases (CRLM), laboratory testing of irinotecan-eluting microspheres, and clinical evaluation in 35 patients with…

Liver IntNov 3, 2026Read summary
Clinical ResearchOncology (Medical)Open access

Spatial transcriptomics tumor microenvironment determinants of tyrosine kinase inhibitor response in renal cell carcinoma: results from a phase 2 clinical trial.

This phase 2 clinical trial examined whether spatially resolved tumor gene-expression patterns were associated with sunitinib response in 46 patients with metastatic clear cell renal cell carcinoma.

Signal Transduct Target TherNov 10, 2026Read summary
Clinical ResearchOncology (Medical)Open access

Biomarker Modulation by Aspirin and Metformin for Colorectal Cancer Prevention: Results from the ASAMET Randomized Phase II Trial.

The multicenter, double-blind, 2 × 2 factorial phase II ASAMET randomized trial evaluated aspirin, metformin, and their combination for 12 months in patients with resected stage I to III colorectal cancer.

Cancer Res CommunNov 1, 2026Read summary
Clinical ResearchNeurology

The shared genetic architecture of the TDP-43 spectrum: Bridging clinical FTLD and neuropathological endophenotypes.

This inverse-variance fixed-effects and random-effects meta-analysis examined shared genetic associations across neuropathological TDP-43 conditions and clinically diagnosed frontotemporal lobar degeneration (FTLD).

Alzheimers DementNov 1, 2026Read summary
Clinical ResearchInfectious Diseases

The characteristics of men who have sex with men presenting with oral syphilis: a systematic review.

This systematic review described demographic, behavioural, co-infection and clinical features of men who have sex with men (MSM) presenting with oral syphilis.

Sex HealthNov 9, 2026Read summary

Showing 12 of 79 publications that cleared our clinical screen in the last 14 days.

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