Tubulo-Squamous Vaginal Polyp: A Clinicopathologic Series with Literature Review.
Bushra K Al-Tarawneh, Sadeq Islam, M Ruhul Quddus et al.
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Case in brief
The authors describe six tubulo-squamous polyps of the vagina identified in routine practice. These benign, upper-vaginal lesions occur in postmenopausal women. Histology showed submucosal, mass-forming lesions with cystic metaplastic transitional-type epithelium and prostate-like glands. Their histological and immunohistochemical features matched metaplastic changes reported in cervical and vaginal Müllerian epithelium with exogenous testosterone exposure. The lesion’s origin remains uncertain; misplaced prostate-like vaginal Skene glands are a proposed source.
What made this case unusual
The polyps’ histological and immunohistochemical profile resembles cervical and vaginal Müllerian epithelial metaplasia associated with exogenous testosterone exposure, although the abstract does not establish a causal link or report testosterone exposure in these cases.
Diagnostic / clinical pearl
Recognize the combination of submucosal cystic transitional-type metaplasia and prostate-like glands as characteristic of vaginal tubulo-squamous polyp; its proposed origin remains uncertain.