The First Report of BRAF V600E Mutation in Paratesticular Mesothelioma.

Int J Surg PatholJun 4, 2026 (epub)
Case ReportPathology (Anatomic & Clinical)UrologyOncology (Medical)

Ting Zhao, Yin P Hung, Adam S Fisch et al.

✦ AI-curated · Sources linked

Case in brief

A 44-year-old man with a history of asbestos exposure presented with painless right testicular swelling. Orchiectomy showed a 1.5-cm biphasic paratesticular mesothelioma, predominantly sarcomatoid (80%) with an epithelioid component (20%). The tumor expressed mesothelial markers, with BAP1, MTAP, and Merlin expression intact. Next-generation sequencing identified BRAF V600E, confirmed by immunohistochemistry. After adjuvant chemotherapy, he remained free of disease at 11 months of follow-up.

What made this case unusual

The tumor harbored BRAF V600E, a mutation described as exceptionally rare in mesothelioma; this was the first reported paratesticular mesothelioma with this alteration.

Diagnostic / clinical pearl

BRAF V600E can occur in paratesticular mesothelioma, including a biphasic tumor with intact BAP1, MTAP, and Merlin expression; molecular testing and confirmatory immunohistochemistry identified the alteration in this case.

Why it matters

The finding adds a molecular feature to the limited clinicopathologic characterization of paratesticular mesothelioma.

Source

PubMed · PMID 42237856

Published in Int J Surg Pathol. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

ShareTelegramLinkedIn

AI-generated summaries may contain errors or omissions. Verify clinically important information with the original publication.

More in Pathology (Anatomic & Clinical)

Clinical ResearchPreventive Medicine / Public Health

2025 National Guidelines on the Mediterranean Diet: Executive Summary of a Joint Report by Italian Scientific Societies and the National Institute of Health Task Force on Clinical Practice Guidelines.

This systematic review and practice guideline, developed by a multidisciplinary panel using NUTRIGRADE, assessed Mediterranean diet evidence across nine health domains and one economic domain.

Nutr RevNov 12, 2026Read summary
Clinical ResearchOrthopedic Surgery

Prevention of Venous Thromboembolism after Total Hip or Knee Replacement.

This multicenter randomized comparative-effectiveness noninferiority trial compared 30 days of aspirin, warfarin, or rivaroxaban for VTE prophylaxis after elective total hip or knee arthroplasty.

N Engl J MedNov 12, 2026Read summary
Clinical ResearchAnesthesiology

Effect of discontinuing antihypertensives on perioperative hypotension in older patients before non-cardiac surgery: multicentre, randomised, double blind, controlled trial.

This multicentre, randomised, double blind, placebo controlled trial assessed whether withholding ACE inhibitors or ARBs on the morning of surgery reduces perioperative hypotension in older adults undergoing non-cardiac…

BMJNov 11, 2026Read summary

Want this personalized?

Stop searching the literature. Choose what you follow and xxcode will build your personalized medical digest.

  • Your specialties
  • Your filters and thresholds
  • Clinical Research + Case Reports, tuned separately
  • Automatic weekly delivery
  • Audio and text
Create my personalized digestSee plans

Prefer listening? Personalized audio digests are available with Pro.

Stay updated for free

Get the 3 most interesting publications in one specialty each week.

Weekly email. Unsubscribe anytime.