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2000 articles
November 202624
Effect of Kunxian capsule, a novel Tripterygium wilfordii preparation, on reducing proteinuria and slowing renal function decline in diabetic kidney disease: a 48-week randomized controlled trial.
This 48-week randomized controlled trial assigned 80 patients with diabetic kidney disease to irbesartan-based standard therapy with or without adjunctive Kunxian capsule.
Late-onset Niemann-Pick C disease in a patient with spastic ataxia and hyperkinetic involuntary movements: a case report.
A woman with late-onset Niemann-Pick disease type C1 presented from age 50 with progressive postural instability, falls, spastic ataxia, and prominent upper-limb hyperkinetic movements.
Severe Atherogenic Dyslipidemia in Ataxia-Telangiectasia Despite Cachexia: Mechanistic Insights into Mitochondrial Dysfunction.
A 25-year-old woman with genetically confirmed ataxia-telangiectasia and extreme underweight (body mass index 12.5 kg/m²) developed severe mixed atherogenic dyslipidemia despite modest dietary fat intake and no…
Spinocerebellar Ataxia Type 6 Concurrent with Normal-Pressure Hydrocephalus: A Case Report.
A 73-year-old man with two years of progressive gait disturbance had gaze-evoked nystagmus, dysarthria, limb ataxia, a broad-based shuffling gait, and urinary urgency.
Liposomal Bupivacaine versus Ropivacaine for Rhomboid Intercostal and Subserratus Plane Blocks in Video-Assisted Thoracoscopic Surgery: A Randomised Controlled Trial.
This single-centre randomised controlled trial compared liposomal bupivacaine (LB) with ropivacaine (RP) for ultrasound-guided rhomboid intercostal and subserratus plane blocks in patients undergoing video-assisted…
Extended in vivo activity of VRC01 HIV-1 prophylaxis entails initial protective efficacy and subsequent breakthrough infections.
The two parallel randomized antibody-mediated prevention trials assessed whether intravenous VRC01 prevented HIV-1 acquisition, with this analysis extending follow-up through the week 104 final visit.
The Harvesting Oblique Tuberosity (HOT) Technique: A Simplified Clinical Approach for Standardized Connective Tissue Graft Retrieval.
This clinical report presents the harvesting oblique tuberosity (HOT) technique for retrieving autogenous connective tissue grafts from the maxillary tuberosity.
Pseudo-Metabolic Alkalosis: A Hidden Laboratory Pitfall With Elevated LDH.
A 33-year-old man presented with progressive exertional dyspnea, syncope, and paresthesia. Testing showed pancytopenia, macrocytosis, LDH >3600 U/L, low haptoglobin, and vitamin B₁₂ <68 pg/mL, consistent with pernicious…
Coexistence of ARNT::ALK and TPM3::ALK doublegene fusion in an ALK-rearranged renal cell carcinoma with osseous metaplasia.
An adult patient had an ALK-rearranged renal cell carcinoma. The tumor showed varied growth patterns in a mucinous background, with a small peripheral focus of osseous metaplasia.
Surgical Procedure to Optimize the Esthetic and Osseous Outcomes for Young Adults with Large Periradicular Defects: Two Case Reports.
The report describes two young adults with teeth affected by internal root resorption or persistent large periapical lesions after nonsurgical endodontic treatment.
Reconstruction of the Burned Nose Using an Expanded Skin-Grafted Forehead Flap, Delayed Turnover Flaps, and Indocyanine Green Perfusion Assessment.
A 35-year-old man developed severe nasal deformity and airway compromise after a flame burn involving about 20% of total body surface area.
Validity of the 2023 ACR/EULAR APS classification criteria for paediatric primary APS: inputs from a systematic literature review.
This systematic literature review and individual participant data-style random-effects meta-analysis assessed the 2023 ACR/EULAR antiphospholipid syndrome (APS) classification criteria in children with primary APS.
Immune checkpoints inhibitors in the treatment of progressive multifocal leukoencephalopathy: A systematic review and meta-analysis.
This systematic review and meta-analysis assessed immune checkpoint inhibitors (ICIs) for progressive multifocal leukoencephalopathy (PML), pooling reports involving 186 patients from 52 articles.
Late Gastric Remnant Necrosis Associated with Paraesophageal Hernia After Roux-en-Y Gastric Bypass.
A 65-year-old man presented nearly 20 years after Roux-en-Y gastric bypass with acute left upper quadrant pain, nausea, and vomiting.
Systemic corticosteroids in critical illness: an evidence-based framework for clinical decision-making.
This systematic review qualitatively synthesized randomized trials, reviews, and meta-analyses to develop a decision framework for systemic corticosteroids in severe community-acquired pneumonia (sCAP), acute…
Shotgun metagenomic characterization of human adenovirus F40 and a non-cpe Clostridium perfringens strain in pediatric prolonged diarrhea: a genome-resolved case study.
A child with prolonged diarrhea had adenovirus identified as the sole pathogen by routine testing. Shotgun metagenomic sequencing of stool confirmed human adenovirus F40 (HAdV-F40), phylogenetically distinct from…
Imaging Modalities to Visualize Deep Cerebral Perforating Arteries: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed imaging methods for visualizing deep cerebral perforating arteries in human studies.
Effectiveness of home-based exercise interventions on cardiorespiratory fitness and cancer treatment-related cardiovascular toxicity in cancer survivors exposed to cardiotoxic therapies: a systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis of randomized controlled trials assessed structured home-based exercise in cancer survivors exposed to cardiotoxic therapies. Ten trials involving 851 participants were included.
Robotic-assisted total knee arthroplasty demonstrates superior early functional outcomes compared with conventional total knee arthroplasty: a quasi-randomised controlled trial.
This quasi-randomised controlled trial compared 1-year outcomes after primary total knee arthroplasty (TKA) in 845 patients treated with robotic-assisted or conventional workflows at one institution.
Risk factors for cognitive impairment in patients undergoing hemodialysis: an umbrella review and meta-analysis.
This umbrella review and meta-analysis examined factors associated with cognitive impairment and cognitive frailty in adults receiving maintenance hemodialysis. It included five meta-analyses covering 97 associations.
Stereotactic radiosurgery for bilateral trigeminal neuralgia: A systematic review and proposed framework for staged treatment.
This systematic review assessed stereotactic radiosurgery (SRS) for medically refractory bilateral trigeminal neuralgia (BTN) in adults.
Carpal Osteomyelitis Caused by Mycobacterium Intracellulare Treated with Vascularized Bone Graft Reconstruction: A Case Report.
An 81-year-old man had progressive wrist swelling over 5 years, with diffuse carpal destruction attributed to Mycobacterium intracellulare osteomyelitis.
Barriers to Gender-Affirming Care for Nonbinary People: A Systematic-Narrative Hybrid Literature Review.
This systematic-narrative hybrid literature review synthesised qualitative, quantitative and mixed-methods research, alongside systematic and scoping reviews, on barriers to gender-affirming care for nonbinary people.
Clinical, neuroimaging and electroencephalographic differences between pediatric and adult HaNDL: a systematic review and pooled individual patient analysis.
This PRISMA 2020-guided systematic review and pooled individual patient analysis compared clinical and ancillary findings in pediatric and adult patients with HaNDL, a self-limited headache syndrome with cerebrospinal…
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