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557 articles
September 202619
Phenome- and laboratory-wide meta-analyses of sickle cell trait reveal multi-system disease associations.
This meta-analysis examined the health outcomes associated with sickle cell trait (SCT) in 4,813 individuals of African genetic ancestry.
Successful immune tolerance induction using efanesoctocog alfa in severe hemophilia A: a case series.
Two patients with severe hemophilia A and complex histories of FVIII inhibitors received immune tolerance induction with efanesoctocog alfa, initially at 100 U/kg three times weekly.
Life-threatening multisystem sarcoidosis with neurological, renal, ocular and autoimmune haemolytic manifestations treated with intravenous immunoglobulin, plasma exchange, cyclophosphamide and infliximab.
A patient with multisystem sarcoidosis presented with encephalopathy, acute tubulointerstitial nephritis, optic neuritis, and autoimmune hemolytic anemia, resembling a stroke.
Fatal Transfusion-transmitted Severe Dengue in an Immunocompromised Host: Case Report and Systematic Literature Review.
A stem cell transplant recipient developed severe dengue following a blood transfusion during the 2024 dengue epidemic in Brazil.
Pain Management in Erythromelalgia: A Systematic Review and Graded Appraisal Across Etiological Subtypes.
This systematic review evaluated pain management strategies for erythromelalgia across various etiological subtypes, analyzing 25 studies involving 591 individuals.
Comparative Efficacy of BTK Inhibitors in Treatment-Naïve and Relapsed/Refractory Mantle Cell Lymphoma: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis evaluated the efficacy of Bruton tyrosine kinase inhibitors (BTKis) in treatment-naïve and relapsed/refractory mantle cell lymphoma (MCL).
Paraneoplastic Myopathy as a Possible Initial Presentation of Sporadic Burkitt Lymphoma in an Immunocompetent Adult: A Case Report.
An immunocompetent adult male presented with acute progressive proximal muscle weakness and elevated creatine phosphokinase levels. Extensive evaluations ruled out autoimmune and metabolic causes.
Systemic amyloidosis diagnosed by labial salivary gland biopsy.
A man in his 60s presented with acute decompensating heart failure and was initially evaluated for cardiac amyloidosis. Due to difficulties in obtaining a tissue sample, he was referred for a labial salivary gland…
Cardiovascular disease and amyloidosis in phase III multiple myeloma trials: a systematic review of eligibility, screening and event reporting.
This systematic review evaluated phase III randomized controlled trials of multiple myeloma therapies, focusing on eligibility criteria related to cardiovascular disease (CVD) and amyloidosis.
Case Report and Retrospective Review of Acanthamoeba Encephalitis and Chronic Lymphocytic Leukemia, United States.
A patient with chronic lymphocytic leukemia (CLL) presented with Acanthamoeba encephalitis. The case highlights the association between CLL and Acanthamoeba infections, noting that CLL is the most common underlying…
Neoehrlichiosis Causing Hemolytic Anemia in Patients Treated with Rituximab, Norway, 2024-2025.
Three rituximab-treated patients in Norway presented with direct antiglobulin test-negative hemolytic anemia due to Neoehrlichia mikurensis infection.
A Phase 1 Trial of Duvelisib and Oral Azacitidine in Relapsed/Refractory T-Cell Lymphoma.
This Phase I trial evaluated the combination of duvelisib and oral azacitidine in 14 patients with relapsed/refractory T-cell lymphoma.
Convalescent Plasma Restores Viral Clearance After Anti-Spike Monoclonal Antibody Failure in Immunocompromised COVID-19 Patients: A Systematic Review and Meta-Analysis of Individual Patient Data.
This systematic review and meta-analysis evaluated the effectiveness of convalescent plasma (CCP) in immunocompromised COVID-19 patients who remained positive for SARS-CoV-2 after anti-Spike monoclonal antibody (mAb)…
Amyloid-Like Immunoglobulin Deposition Neuropathy.
A case of amyloid-like immunoglobulin deposition neuropathy was presented, characterized by predominant neuropathic pain, skin changes, and progressive distal sensory neuropathy.
Type 1 Diabetes Driven by Residual Recipient T Cells After Hematopoietic Cell Transplantation: A Case Report.
A patient developed type 1 diabetes following haploidentical hematopoietic cell transplantation. Analysis revealed an expanded population of islet-specific CD4+ T cells in the recipient, predominantly restricted by…
Iron overload disorders in adults: a comprehensive review of gonadal function, reproductive, and sexual health.
This systematic review examined gonadal function, fertility, sexual health, and pregnancy outcomes in adults with iron overload disorders, including thalassaemias, hereditary haemochromatosis, and transfusion-dependent…
Wartime Occurrence of Severe Aplastic Anemia in Previously Healthy Military Service Members: A Case Series.
Three previously healthy military service members developed idiopathic severe aplastic anemia (SAA) during active duty, presenting with cytopenias and hemorrhagic symptoms.
Tandem Double Inversion Resolves the Structural Paradox Underlying Recurrent KAT6A::NCOA2 Fusion in Acute Myeloid Leukemia.
A case of acute myeloid leukemia (AML) presented with the rare KAT6A::NCOA2 fusion, typically associated with inv(8)(p11q13). Genomic profiling revealed an unexpected MTFR1::KAT6A rearrangement.
XY0206 targets FLT3-dependent resistance states in acute myeloid leukemia.
This phase I/II clinical trial evaluated XY0206 monotherapy in patients with relapsed or refractory acute myeloid leukemia (AML), alongside laboratory and animal studies of its FLT3-directed activity.
August 20265
Efficacy and Safety of Ropeginterferon Alfa-2b in Pregnant Women With Myeloproliferative Neoplasms: Case Series of Three Subtypes and Review.
This case series reports on four pregnancies in women with myeloproliferative neoplasms (MPNs), including prefibrotic myelofibrosis, essential thrombocythemia, and polycythemia vera.
Clinical features, genetic analysis, and efficacy evaluation of hematopoietic stem cell transplantation in a case of osteopetrosis caused by compound heterozygous variations in the TNFRSF11A gene: a case study.
A three-year-old Chinese girl with osteopetrosis presented with recurrent fractures, short stature, and macrocephaly. Radiological findings showed elevated bone mineral density and constricted medullary spaces.
Phase II Study of Posttransplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis After HLA-Mismatched Unrelated Donor Reduced Intensity Transplantation: Results From the ACCESS Trial Expansion Cohort.
This prospective, multicenter phase II study evaluated posttransplant cyclophosphamide (PTCy)-based graft-versus-host disease prophylaxis in adults receiving peripheral blood stem cell transplantation from…
VEXAS Syndrome：Report of One Case.
An elderly male presented with fatigue and fever, later developing macrocytic anemia, tracheal and bronchial wall thickening, polyarthritis, rashes, and elevated inflammatory markers.
Prothrombin complex concentrate (PCC) vs. non-PCC strategies for warfarin reversal in left ventricular assist device recipients: A systematic review and meta-analysis.
This systematic review and meta-analysis evaluated prothrombin complex concentrate (PCC) versus non-PCC strategies for warfarin reversal in left ventricular assist device (LVAD) recipients.
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