VEXAS Syndrome：Report of One Case.

Zhongguo Yi Xue Ke Xue Yuan Xue BaoAug 30, 2026
Case ReportHematologyMedical GeneticsRheumatology

Hui-Ting Liu, Jia-Xin Zhou, Ruo-Xi Zhang et al.

✦ AI-curated · Sources linked

Case in brief

An elderly male presented with fatigue and fever, later developing macrocytic anemia, tracheal and bronchial wall thickening, polyarthritis, rashes, and elevated inflammatory markers. A bone marrow smear revealed vacuolar degeneration in immature granulocytes, leading to UBA1 gene testing that confirmed VEXAS syndrome. Glucocorticoid therapy improved his condition, but he experienced recurrence of fever and anemia months after treatment cessation.

Diagnostic / clinical pearl

The diagnosis of VEXAS syndrome can be supported by identifying vacuolar degeneration in immature granulocytes on a bone marrow smear, highlighting the importance of integrating clinical and laboratory findings.

Source

PubMed · PMID 42660847

Published in Zhongguo Yi Xue Ke Xue Yuan Xue Bao. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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