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Important medical research and remarkable case reports worth knowing.

Selected from high-relevance medical literature published in the last 14 days.

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FeaturedClinical ResearchHematology

Azacitidine-Venetoclax or Induction Chemotherapy for Acute Myeloid Leukemia.

N Engl J MedSep 3, 2026

This phase 2 randomized trial compared azacitidine plus venetoclax to induction chemotherapy in 172 previously untreated adults with acute myeloid leukemia (AML) eligible for induction.

Why it matters

The findings suggest that azacitidine-venetoclax may offer a more effective treatment option with a better safety profile for induction-eligible patients with AML, potentially changing standard treatment approaches.

Read summary

Also worth knowing

Clinical ResearchHematology

Concizumab in patients with hemophilia A or B without inhibitors: 56-week cutoff results of the phase 3 explorer8 study.

The phase 3 explorer8 study evaluated concizumab, a nonfactor replacement therapy, in males aged ≥12 years with hemophilia A or B without inhibitors.

Blood AdvSep 6, 2026Read summary
Clinical ResearchHematology

Comparative Efficacy of BTK Inhibitors in Treatment-Naïve and Relapsed/Refractory Mantle Cell Lymphoma: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis evaluated the efficacy of Bruton tyrosine kinase inhibitors (BTKis) in treatment-naïve and relapsed/refractory mantle cell lymphoma (MCL).

J Cell Mol MedSep 1, 2026Open accessRead summary
Clinical ResearchHematology

Outcomes of patients with myelofibrosis treated with ruxolitinib and anemia-supporting medications.

This post hoc analysis of the phase 3b JUMP trial examined the effects of adding anemia-supporting medications to ruxolitinib in 101 patients with myelofibrosis and anemia.

HematologySep 4, 2026Read summary
Clinical ResearchHematology

Frontline therapies for adult patients with newly diagnosed Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia: a systematic literature review.

This systematic review evaluated 96 studies on frontline therapies for adults with Philadelphia chromosome-negative B-cell acute lymphoblastic leukemia (B-ALL).

HematologySep 8, 2026Read summary
Clinical ResearchHematology

Baricitinib for refractory chronic graft-versus-host disease: results of a phase 1/2 study.

This phase 1/2 study evaluated the safety and efficacy of baricitinib, a JAK 1/2 inhibitor, in 24 adults with refractory chronic graft-versus-host disease (cGVHD) after hematopoietic cell transplantation.

Blood AdvSep 6, 2026Open accessRead summary
Clinical ResearchCardiology

Prothrombin complex concentrate (PCC) vs. non-PCC strategies for warfarin reversal in left ventricular assist device recipients: A systematic review and meta-analysis.

This systematic review and meta-analysis evaluated prothrombin complex concentrate (PCC) versus non-PCC strategies for warfarin reversal in left ventricular assist device (LVAD) recipients.

Intensive Crit Care NursAug 29, 2026Read summary
Clinical ResearchInfectious Diseases

Convalescent Plasma Restores Viral Clearance After Anti-Spike Monoclonal Antibody Failure in Immunocompromised COVID-19 Patients: A Systematic Review and Meta-Analysis of Individual Patient Data.

This systematic review and meta-analysis evaluated the effectiveness of convalescent plasma (CCP) in immunocompromised COVID-19 patients who remained positive for SARS-CoV-2 after anti-Spike monoclonal antibody (mAb)…

Rev Med VirolSep 1, 2026Open accessRead summary
Case ReportHematology

Acute haemolytic anaemia precipitated by fava bean ingestion in a patient with previously undiagnosed glucose-6-phosphate dehydrogenase deficiency.

A patient with previously undiagnosed glucose-6-phosphate dehydrogenase (G6PD) deficiency developed acute haemolytic anaemia after consuming fava bean snacks.

BMJ Case RepSep 5, 2026Read case
Case ReportHematology

Tuberculosis presenting as dual immune dysregulation: Evans syndrome and haemophagocytic lymphohistiocytosis.

A middle-aged man with no prior health issues presented with a month-long history of fever, dry cough, weight loss, and worsening breathlessness.

BMJ Case RepSep 5, 2026Read case
Case ReportHematology

Blinatumomab-induced catastrophic immune effector cell-associated neurotoxicity with diffuse cerebral edema in a patient with ALL: Case report.

A 13-year-old boy with MLL-AF4-positive precursor B-ALL developed catastrophic neurotoxicity during blinatumomab therapy. After initially tolerating treatment, he experienced fever on day 13 of the second cycle, leading…

Int J Clin Pharmacol TherSep 9, 2026Read case
Case ReportInfectious Diseases

Fatal Transfusion-transmitted Severe Dengue in an Immunocompromised Host: Case Report and Systematic Literature Review.

A stem cell transplant recipient developed severe dengue following a blood transfusion during the 2024 dengue epidemic in Brazil.

Clin Infect DisSep 2, 2026Read case

Showing 12 of 44 publications that cleared our clinical screen in the last 14 days.

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