Paraneoplastic Myopathy as a Possible Initial Presentation of Sporadic Burkitt Lymphoma in an Immunocompetent Adult: A Case Report.
Abolfazl Khalafi-Nezhad, Dena Firouzabadi, Vahid Mohammadkarimi et al.
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Case in brief
An immunocompetent adult male presented with acute progressive proximal muscle weakness and elevated creatine phosphokinase levels. Extensive evaluations ruled out autoimmune and metabolic causes. Imaging revealed left axillary lymphadenopathy and splenomegaly, leading to a diagnosis of sporadic Burkitt's lymphoma confirmed by biopsy. The patient received chemotherapy, resulting in rapid improvement in muscle strength and a decrease in CPK levels.
What made this case unusual
Paraneoplastic myopathy as the initial presentation of Burkitt's lymphoma is exceedingly uncommon in immunocompetent adults.
Diagnostic / clinical pearl
Clinicians should consider hematologic malignancies in patients with unexplained myopathy and elevated muscle enzymes, as early diagnosis can improve outcomes.