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Important medical research and remarkable case reports worth knowing.

Selected from high-relevance medical literature published in the last 14 days.

FeaturedClinical ResearchPreventive Medicine / Public Health

2025 National Guidelines on the Mediterranean Diet: Executive Summary of a Joint Report by Italian Scientific Societies and the National Institute of Health Task Force on Clinical Practice Guidelines.

Nutr RevNov 12, 2026

This systematic review and practice guideline, developed by a multidisciplinary panel using NUTRIGRADE, assessed Mediterranean diet evidence across nine health domains and one economic domain.

Why it matters

The guideline synthesizes evidence across multiple clinical and public health domains, indicating that dietary patterns may be relevant to prevention and outcomes across a broad range of non-communicable diseases.

Read summary

Also worth knowing

Clinical ResearchNeurologyOpen access

Loberamisal for Acute Ischemic Stroke: The LAIS Randomized Clinical Trial.

The LAIS trial was a multicenter, double-blind, randomized, placebo-controlled phase 3 study at 32 hospitals in China. It enrolled adults aged 18 to 80 years with acute ischemic stroke, treated within 48 hours, and…

JAMANov 10, 2026Read summary
Clinical ResearchNeurologyOpen access

Efficacy and safety of selective orexin 2 receptor agonists in narcolepsy type 1: a systematic review and meta-analysis of randomized controlled trials.

This systematic review and meta-analysis pooled randomized, double-blind, placebo-controlled trials of oral selective orexin 2 receptor agonists in people with narcolepsy type 1.

J NeurolNov 11, 2026Read summary
Clinical ResearchNeurologyOpen access

Tenecteplase Before Thrombectomy at 4.5 to 24 Hours for Basilar Artery Occlusion: The ATTENTION LATE Randomized Clinical Trial.

This multicenter, open-label, blinded-endpoint randomized clinical trial compared intravenous tenecteplase before endovascular thrombectomy (EVT) with EVT alone in patients with moderate to severe basilar artery…

JAMANov 3, 2026Read summary
Clinical ResearchNeurology

Severity-Based Triage for Direct Transportation to Nearest Comprehensive Stroke Center: A Systematic Review and Meta-Analysis.

This systematic review and meta-analysis assessed prehospital bypass of the nearest stroke center for direct transport to a more distant comprehensive stroke center in patients with suspected stroke.

NeurologyNov 10, 2026Read summary
Clinical ResearchPsychiatryOpen access

Effectiveness of guided internet-delivered cognitive behavioral therapy for insomnia in autistic adults (i-Sleep Autism): a randomized controlled trial.

This randomized controlled trial evaluated a 5-week, guided internet-delivered cognitive behavioral therapy intervention adapted for autistic adults with insomnia.

SleepNov 10, 2026Read summary
Clinical ResearchNeurologyOpen access

Efficacy of cognitive behavioral therapy for anxiety and depression symptoms in Parkinson's disease patients: a systematic review and meta-analysis.

This systematic review and meta-analysis assessed cognitive behavioral therapy (CBT) for anxiety and depressive symptoms in adults with Parkinson’s disease (PD), pooling 21 randomized controlled trials involving 892…

Neurol SciNov 5, 2026Read summary
Clinical ResearchNeurologyOpen access

Subsequent epilepsy surgery after SEEG-guided radiofrequency thermocoagulation: Outcomes and prognostic value of treatment response-a systematic review and meta-analysis.

This systematic review and meta-analysis assessed outcomes after resective, disconnective, or ablative epilepsy surgery in patients previously treated with SEEG-guided radiofrequency thermocoagulation (SEEG-RFTC), and…

Neurosurg RevNov 6, 2026Read summary
Clinical ResearchNeurologyOpen access

Intra-arterial tenecteplase during thrombectomy for acute ischemic stroke: the BRETIS-TNK2 trial.

The phase 3 BRETIS-TNK2 multicentre randomised trial compared intra-arterial tenecteplase during endovascular thrombectomy with thrombectomy alone in patients with large-vessel occlusion eligible for treatment within 24…

Nat CommunNov 6, 2026Read summary
Clinical ResearchNeurologyOpen access

Intra-arterial tenecteplase for acute basilar artery occlusion with sufficient recanalization after thrombectomy: the INSIST-IT randomized clinical trial.

The INSIST-IT multicentre, prospective, randomised trial assessed adjunctive intra-arterial tenecteplase after successful endovascular reperfusion in patients with acute basilar artery occlusion treated within 24 hours…

Nat CommunNov 6, 2026Read summary
Clinical ResearchGeriatrics

Evaluating the accuracy of brief cognitive assessments for the early detection of cognitive impairment in adults across primary and specialty care settings: A systematic review and meta-analysis.

This systematic review and meta-analysis assessed brief, freely available cognitive tests for detecting cognitive impairment, including mild cognitive impairment and dementia, in adults aged 55 years and older in…

Alzheimers DementNov 1, 2026Read summary
Clinical ResearchNeurosurgery

Salovum® reduces mortality in isolated severe traumatic brain injury: a randomized phase II trial.

This prospective, double-blind, placebo-controlled phase II randomized trial tested Salovum® in adults with isolated severe traumatic brain injury receiving intracranial pressure monitoring and neurointensive care at a…

BrainNov 4, 2026Read summary

Showing 12 of 116 publications that cleared our clinical screen in the last 14 days.

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