Fatal Transfusion-transmitted Severe Dengue in an Immunocompromised Host: Case Report and Systematic Literature Review.
Alexandre Mestre Tejo, Amaro Nunes Duarte-Neto, Jacqueline Alves Rena et al.
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Case in brief
A stem cell transplant recipient developed severe dengue following a blood transfusion during the 2024 dengue epidemic in Brazil. Phylogenetic analysis confirmed the transmission of the virus through the transfusion, leading to a fatal outcome. This case underscores the heightened risk of severe dengue in immunocompromised patients receiving transfusions.
Diagnostic / clinical pearl
Clinicians should be aware of the risk of transfusion-transmitted dengue, especially in immunocompromised patients, during dengue outbreaks.
Why it matters
This case emphasizes the need for vigilance in blood safety protocols during dengue epidemics to protect vulnerable populations.