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2000 articles
November 202624
Enhancing Peri-implant Papillae: A Minimally Invasive Approach with Integrated Prosthetic Solutions.
This case series describes four patients with deficient interproximal papillae and soft-tissue contours around implants. The cases included adjacent implants treated with soft-tissue grafting at stage-two surgery or…
Topical MSC-Derived Extracellular Vesicles Accelerate Healing of Second-Degree Burns: A Case Report.
A 48-year-old man with deep second-degree burns received a single topical dose of allogeneic bone marrow mesenchymal stem cell-derived extracellular vesicles within 48 hours of injury in an open-label phase 1/2a study.
Effects of digital stress-management interventions in breast cancer patients 18 months after intervention access.
This randomized controlled trial examined whether app-based cognitive behavioral (CBI) or mindfulness-based (MBI) stress management was associated with improved outcomes 18 months after access began among patients with…
Immune checkpoints inhibitors in the treatment of progressive multifocal leukoencephalopathy: A systematic review and meta-analysis.
This systematic review and meta-analysis assessed immune checkpoint inhibitors (ICIs) for progressive multifocal leukoencephalopathy (PML), pooling reports involving 186 patients from 52 articles.
Effects of Probiotics on Migraine in Children and Adults: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed probiotics for migraine prevention in placebo-controlled trials involving adults and children.
Validity of the 2023 ACR/EULAR APS classification criteria for paediatric primary APS: inputs from a systematic literature review.
This systematic literature review and individual participant data-style random-effects meta-analysis assessed the 2023 ACR/EULAR antiphospholipid syndrome (APS) classification criteria in children with primary APS.
The effect of exercise program applied to patients with scleroderma on functional outcomes: A randomized controlled trial.
This randomized controlled trial assessed whether an exercise program improved hand and mouth function and quality of life in 46 patients with systemic sclerosis.
Severe Atherogenic Dyslipidemia in Ataxia-Telangiectasia Despite Cachexia: Mechanistic Insights into Mitochondrial Dysfunction.
A 25-year-old woman with genetically confirmed ataxia-telangiectasia and extreme underweight (body mass index 12.5 kg/m²) developed severe mixed atherogenic dyslipidemia despite modest dietary fat intake and no…
Maternal and Fetal Outcomes in Pregnant Women with Burn Injuries: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis pooled maternal and fetal mortality in pregnant women with burn injuries, using observational studies and case series.
Histologic Evaluation of Bone Regeneration Using the Subperiosteal Peri-implant Augmented Layer (SPAL) Technique Combined with Deproteinized Bovine Bone Mineral: A Case Report.
Six patients with peri-implant bone dehiscence underwent augmentation using the subperiosteal peri-implant augmented layer (SPAL) technique with particulate deproteinized bovine bone mineral.
Late-onset Niemann-Pick C disease in a patient with spastic ataxia and hyperkinetic involuntary movements: a case report.
A woman with late-onset Niemann-Pick disease type C1 presented from age 50 with progressive postural instability, falls, spastic ataxia, and prominent upper-limb hyperkinetic movements.
Extended in vivo activity of VRC01 HIV-1 prophylaxis entails initial protective efficacy and subsequent breakthrough infections.
The two parallel randomized antibody-mediated prevention trials assessed whether intravenous VRC01 prevented HIV-1 acquisition, with this analysis extending follow-up through the week 104 final visit.
Longitudinal remodeling of the tumor-immune microenvironment during regorafenib, nivolumab, and chemotherapy in advanced gastric cancer.
This phase 1b/2 clinical trial evaluated first-line regorafenib, nivolumab, and chemotherapy in 30 patients with mismatch repair-proficient advanced gastric cancer, alongside longitudinal analysis of tumor biopsies.
Efficacy and safety of cenobamate in the treatment of drug-resistant epilepsy: a systematic review and meta-analysis in adult, pediatric, and combined populations.
This systematic review and random-effects meta-analysis assessed cenobamate efficacy and safety for drug-resistant epilepsy in adults, children, and mixed-age populations.
Proton pump inhibitors in prevention of cisplatin-induced nephrotoxicity: a systematic review.
This systematic review assessed whether proton pump inhibitor (PPI) co-administration prevents cisplatin-related kidney injury and whether it is safe.
Coronary artery calcification is not associated with survival in advanced gastric and gastroesophageal junction cancer: a secondary analysis of the EXPAND trial.
This secondary analysis of baseline CT images from the phase III EXPAND trial assessed whether coronary artery calcification (CAC) predicted overall survival in 785 patients with unresectable locally advanced or…
Risk factors for cognitive impairment in patients undergoing hemodialysis: an umbrella review and meta-analysis.
This umbrella review and meta-analysis examined factors associated with cognitive impairment and cognitive frailty in adults receiving maintenance hemodialysis. It included five meta-analyses covering 97 associations.
Fluid choice in pediatric diabetic ketoacidosis: a Systematic Review and Meta-Analysis.
This systematic review and meta-analysis compared balanced electrolyte solutions (BES) with 0.9% saline for fluid resuscitation in children with diabetic ketoacidosis (DKA), including randomized trials and observational…
Multidisciplinary Single Stage Surgical Management of Advanced Breast Carcinoma With Concomitant Left Atrial Myxoma.
A 58-year-old woman with locally advanced invasive mucinous breast carcinoma had a progressive fungating mass despite neoadjuvant chemotherapy and radiotherapy.
Spatial Acid-Associated Niches Inform Irinotecan-Based DEB-TACE in Colorectal Liver Metastases: A Multicentre Randomized Trial.
This multicentre randomised trial combined transcriptomic and spatial analyses of colorectal liver metastases (CRLM), laboratory testing of irinotecan-eluting microspheres, and clinical evaluation in 35 patients with…
Singing-based interventions for motor and non-motor symptoms in Parkinson's disease: a systematic review.
This systematic review examined interventional studies of singing-based rehabilitation for motor and non-motor symptoms in people with Parkinson’s disease.
Digital Outreach to Improve Statin Refills in Patients With Low Statin Adherence: The ADHERE-ASCVD Randomized Clinical Trial.
The ADHERE-ASCVD pragmatic, health system-embedded randomized clinical trial tested adaptive digital outreach to prompt statin refills among adults with established ASCVD or high ASCVD risk and recent nonadherence.
Chronic erythema nodosum leprosum in Hansen's disease: a challenging clinical management.
A 34-year-old Moroccan man with multibacillary Hansen’s disease developed chronic erythema nodosum leprosum (ENL), with recurrent systemic and cutaneous flares requiring prolonged immunomodulatory treatment.
Examining individual and school-level predictors of positive attitudes towards condom use among adolescents in Tanzania: An exploratory analysis using hierarchical linear modeling.
This exploratory analysis examined individual and school-level correlates of attitudes toward condom use among Standard 7 adolescents in two Tanzanian districts.
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