Chronic erythema nodosum leprosum in Hansen's disease: a challenging clinical management.

Trans R Soc Trop Med HygNov 3, 2026
Case ReportDermatologyInfectious Diseases

Michele Spinicci, Anna Barbiero, Tommaso Manciulli et al.

✦ AI-curated · Sources linked

Case in brief

A 34-year-old Moroccan man with multibacillary Hansen’s disease developed chronic erythema nodosum leprosum (ENL), with recurrent systemic and cutaneous flares requiring prolonged immunomodulatory treatment. Corticosteroids, thalidomide, azathioprine, methotrexate, and anti-TNF-α therapy each provided incomplete control. After six years of recurrent disease and several hospitalizations, a regimen of methylprednisolone, high-dose thalidomide, and clofazimine achieved sustained remission, permitting gradual discontinuation of treatment.

What made this case unusual

Despite trials of multiple immunomodulatory agents, including anti-TNF-α therapy, control remained incomplete until the combination of methylprednisolone, high-dose thalidomide, and clofazimine was used.

Diagnostic / clinical pearl

Chronic ENL can remain difficult to control despite several immunomodulatory approaches; this case describes sustained remission with combined methylprednisolone, high-dose thalidomide, and clofazimine.

Source

PubMed · PMID 42631419

Published in Trans R Soc Trop Med Hyg. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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