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980 articles
November 202624
The Safety, Pharmacokinetics, and Antiviral Activity of ABI-4334, A Novel Next-Generation Hepatitis B Capsid Assembly Modulator.
Two randomized Phase 1 studies assessed ABI-4334, a hepatitis B capsid assembly modulator, in healthy volunteers and participants with chronic hepatitis B (cHBV).
Measles-like hypermutation of a Newcastle disease virus drives fatal encephalitis during BCMA × CD3 T-cell-redirecting immunotherapy.
A patient with multiple myeloma receiving maintenance teclistamab, daratumumab, and lenalidomide developed rapidly progressive brainstem-cerebellar encephalitis.
Cannula exchange for refractory cannula infections during Berlin Heart EXCOR support: a case report.
A 4-year-old girl with truncus arteriosus and severe heart failure received Berlin Heart EXCOR (BHE) support after complex cardiac surgery.
Multidisciplinary management of disseminated tuberculosis with tuberculous meningitis and active hepatitis B in a critically ill pregnant woman in the third trimester: a case report.
A 24-year-old woman at 30 weeks’ gestation presented with headache, vomiting, fever, and nuchal rigidity. Cerebrospinal fluid findings confirmed tuberculous meningitis, and chest CT showed diffuse miliary nodules…
The characteristics of men who have sex with men presenting with oral syphilis: a systematic review.
This systematic review described demographic, behavioural, co-infection and clinical features of men who have sex with men (MSM) presenting with oral syphilis.
Clinical Reasoning: A 33-Year-Old Man With Rapidly Progressive Ataxia.
A 33-year-old man with AIDS developed subacute progressive confusion, blurred vision, diplopia, and generalized cerebellar ataxia after hospitalizations for opportunistic infections.
Barriers and facilitators to HPV vaccination among adult men: A systematic review and qualitative meta-synthesis.
This qualitative systematic review and meta-synthesis examined barriers and facilitators to HPV vaccination among adult men and how healthcare services address vaccination needs.
Triple immune impairment in an elderly patient with IgG4-AIP and MGUS complicated by dual severe infections over 3 years: A case report.
An 82-year-old man with IgG4-related autoimmune pancreatitis and IgGλ monoclonal gammopathy of undetermined significance had markedly elevated serum IgG4 and a monoclonal paraprotein at baseline.
Synchronous hepatocellular carcinoma and nasopharyngeal carcinoma in a patient with chronic hepatitis B: A case report and literature review.
A 63-year-old Chinese man with chronic hepatitis B was found on routine screening to have a liver mass and reported nasal obstruction.
Intestinal tuberculosis with multiple intestinal perforations in a 5-month-old infant: The role of metagenomic next-generation sequencing: a case report and literature review.
A 5-month-old boy presented with fever and abdominal distension that progressed to intestinal obstruction and multiple perforations involving the distal ileum and appendiceal region.
Stellate Ganglion Block for Treatment of Refractory Sympathetic Storm in Severe Tetanus: A Case Report.
A 67-year-old man developed severe tetanus after a bamboo-skewer puncture wound to his left middle finger; the foreign body remained embedded for 3 days before he removed it himself, and he received no systematic…
Cutaneous Aspergillosis Among Extremely Preterm Neonates in Neonatal Intensive Care Units - Michigan and New York, 2023-2024.
Cutaneous aspergillosis is a rare, life-threatening fungal infection in neonates, particularly those born extremely preterm (gestational age <28 weeks); outbreaks have been linked to environmental sources of Aspergillus…
Recovery after more than one month of dialysis in legionella-associated acute kidney injury: a case evaluated with gallium-67 scintigraphy and renal biopsy.
A 73-year-old man developed dialysis-dependent acute kidney injury during severe Legionella pneumonia. Although the infection resolved and antibiotics had been stopped, kidney injury persisted for more than a month.
Spontaneous Colonic Migration of a Ventriculoperitoneal Shunt Catheter.
A 63-year-old man developed fever, somnolence, and elevated inflammatory markers 2.5 years after ventriculoperitoneal shunt placement.
Human granulocytic anaplasmosis acquired in Switzerland: a case report.
A man in his early seventies taking methotrexate for ankylosing spondylitis and with tick exposure developed fever, headache and dizziness, followed by somnolence, dysarthria, ataxia and diplopia.
Health-related quality of life measures in chronic pulmonary aspergillosis: a systematic review of psychometric validity.
This systematic review assessed health-related quality-of-life (HRQoL) measures and symptom scores used in chronic pulmonary aspergillosis (CPA), synthesising evidence from English-language studies published through May…
Extended in vivo activity of VRC01 HIV-1 prophylaxis entails initial protective efficacy and subsequent breakthrough infections.
The two parallel randomized antibody-mediated prevention trials assessed whether intravenous VRC01 prevented HIV-1 acquisition, with this analysis extending follow-up through the week 104 final visit.
Immune checkpoints inhibitors in the treatment of progressive multifocal leukoencephalopathy: A systematic review and meta-analysis.
This systematic review and meta-analysis assessed immune checkpoint inhibitors (ICIs) for progressive multifocal leukoencephalopathy (PML), pooling reports involving 186 patients from 52 articles.
Systemic corticosteroids in critical illness: an evidence-based framework for clinical decision-making.
This systematic review qualitatively synthesized randomized trials, reviews, and meta-analyses to develop a decision framework for systemic corticosteroids in severe community-acquired pneumonia (sCAP), acute…
Aortic Mycetoma with Exserohilum .
A patient developed neurologic symptoms two months after root-sparing repair of an ascending aortic aneurysm and aortic valve replacement.
Multidrug-resistant (MDR) Salmonella Typhi spondylodiscitis with vertebral collapse: a case report.
A 49-year-old woman with diabetes and hypertension developed persistent back pain after enteric fever. Imaging showed spondylodiscitis with vertebral collapse, raising concern for tuberculosis or metastatic disease.
Rifamycin use and gut microbial antibiotic resistance genes in cirrhosis: Results from a double-blind, placebo-controlled clinical trial.
This double-blind, placebo-controlled randomized trial assessed changes in gut antimicrobial resistance genes (ARGs) with rifamycin SV MMX (RiVM) in patients with compensated cirrhosis.
Carpal Osteomyelitis Caused by Mycobacterium Intracellulare Treated with Vascularized Bone Graft Reconstruction: A Case Report.
An 81-year-old man had progressive wrist swelling over 5 years, with diffuse carpal destruction attributed to Mycobacterium intracellulare osteomyelitis.
Variation in recommendations for management of pediatric fever and neutropenia across databases and languages: A systematic review of clinical practice guidelines.
This systematic review and content analysis examined evidence-based clinical practice guidelines (CPGs) for fever and neutropenia in children, assessing how database indexing and publication language affected guideline…
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