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2000 articles
November 202624
Tegmental Heterotopia in PHACE Syndrome: A Previously Undescribed Feature.
The report describes two infants with PHACE syndrome and infratentorial neuroglial heterotopia involving the tectal plate. A 6-week-old infant with a right segmental facial hemangioma and ventricular septal defect had…
Carpal Osteomyelitis Caused by Mycobacterium Intracellulare Treated with Vascularized Bone Graft Reconstruction: A Case Report.
An 81-year-old man had progressive wrist swelling over 5 years, with diffuse carpal destruction attributed to Mycobacterium intracellulare osteomyelitis.
Duodenal Adenocarcinoma Recurrence Limited to the Choledochojejunostomy After Pancreaticoduodenectomy: A Case Suggesting Intraluminal Implantation With a Distinct Mucin Phenotypic Shift.
A 59-year-old man developed recurrence at the choledochojejunostomy 27 months after pancreaticoduodenectomy for duodenal adenocarcinoma, despite five surgically created raw surfaces.
Metagenomic Next-Generation Sequencing of Mycoplasma hominis Infection in an Immunocompromised Patient: A Case Report.
A 52-year-old immunocompromised man developed persistent soft-tissue infection after a wooden splinter injury, with recurrent fever, wound pain, swelling, and exudation.
Risk factors for cognitive impairment in patients undergoing hemodialysis: an umbrella review and meta-analysis.
This umbrella review and meta-analysis examined factors associated with cognitive impairment and cognitive frailty in adults receiving maintenance hemodialysis. It included five meta-analyses covering 97 associations.
Epidemiological, etiological, and antifungal resistance patterns of vulvovaginal Candida spp. infections in Cameroon: A systematic review and meta-analysis.
This systematic review and meta-analysis pooled evidence from 34 studies of vulvovaginal Candida infection and vulvovaginal candidiasis (VVC) in Cameroon.
Shotgun metagenomic characterization of human adenovirus F40 and a non-cpe Clostridium perfringens strain in pediatric prolonged diarrhea: a genome-resolved case study.
A child with prolonged diarrhea had adenovirus identified as the sole pathogen by routine testing. Shotgun metagenomic sequencing of stool confirmed human adenovirus F40 (HAdV-F40), phylogenetically distinct from…
Spatial Acid-Associated Niches Inform Irinotecan-Based DEB-TACE in Colorectal Liver Metastases: A Multicentre Randomized Trial.
This multicentre randomised trial combined transcriptomic and spatial analyses of colorectal liver metastases (CRLM), laboratory testing of irinotecan-eluting microspheres, and clinical evaluation in 35 patients with…
A phase Ia first-in-human study of BPB-101, a novel trifunctional antibody targeting the GARP/TGF-β complex and PD-L1, in patients with locally advanced or metastatic solid tumors.
This phase Ia, multicenter, first-in-human dose-escalation study evaluated BPB-101, a trifunctional antibody targeting the GARP/TGF-β complex and PD-L1, in previously treated patients with advanced or metastatic solid…
Acquired haemophilia B in Kyasanur Forest disease: a case series of isolated prolonged activated partial thromboplastin time.
Nine patients with confirmed acute Kyasanur Forest disease had prolonged activated partial thromboplastin time (APTT) with normal prothrombin time.
Exploratory serum renal biomarker and eGFR responses to high-protein diets during resistance versus concurrent training in resistance-trained men.
This randomized 2 × 2 factorial trial examined renal biomarkers and estimated glomerular filtration rate (eGFR) in resistance-trained men consuming 1.6 or 3.2 g·kg⁻¹·d⁻¹ of protein during 16 weeks of resistance or…
Klippel-Trenaunay Syndrome Prenatal Diagnosis: Two Case Reports and a Review of the Literature.
A report of two fetuses with suspected Klippel-Trenaunay syndrome (KTS) describes prenatal ultrasound findings of marked right-thigh soft-tissue swelling and thickening, with tortuous, dilated arterial and venous…
Co-Designed Text Messaging Intervention for Parents of Children With Early Childhood Caries: Randomized Controlled Trial.
This multisite, assessor-blinded randomized controlled trial evaluated a co-designed, 12-week SMS education and support program for parents of children aged 0 to 6 years with early childhood caries attending six public…
Efficacy of artemisinin derivatives and kelch13 mutations in Plasmodium falciparum: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed ACT efficacy and the distribution of pfk13 mutations in studies of uncomplicated Plasmodium falciparum malaria across Asia, Africa, and the Americas.
Immunothrombosis Biomarkers and Multi-Omics Profiles After Successful Recanalization in Patients Receiving Ischemic Postconditioning: An Exploratory Analysis of the INSPIRE Trial.
This exploratory secondary analysis of the randomized INSPIRE trial examined 60 patients with ischemic stroke after successful endovascular thrombectomy recanalization.
Angiosarcoma in the Setting of Vascular Procedures: A Systematic Review and Our Experiences.
Angiosarcoma is a rare, aggressive endothelial malignancy with a poor prognosis; diagnosis is often delayed by vague symptoms, nonspecific imaging, and challenging histopathology.
Variation in recommendations for management of pediatric fever and neutropenia across databases and languages: A systematic review of clinical practice guidelines.
This systematic review and content analysis examined evidence-based clinical practice guidelines (CPGs) for fever and neutropenia in children, assessing how database indexing and publication language affected guideline…
TIM3 Blockade with Hypomethylating Therapy Restores NK Cell and Cytotoxic CD4+ T-cell Activity in Patients with AML or MDS.
This phase Ib clinical trial examined immune changes in patients with AML or MDS treated with anti-TIM3 sabatolimab plus decitabine.
Pain, sensory acceptability, and treatment compliance following cryotherapy and topical anesthetics in children: A randomized clinical trial.
This randomized clinical trial compared cryotherapy with topical anesthetics in 100 healthy children aged 7–10 years receiving their first dental treatment.
Anterior Chest Wall Tuberculosis Masquerading as a Chronic Parasternal Sinus in an Apparently Immunocompetent Adult: A Diagnostic Challenge in a Resource-Limited Setting.
A previously healthy 22-year-old man presented with an enlarging parasternal-xiphoid swelling and intermittent seropurulent drainage, without respiratory or constitutional symptoms.
Zanubrutinib, obinutuzumab, and venetoclax in CLL: long-term follow up, MRD kinetics, retreatment, T-cell profiling, and PKs.
This phase 2 trial evaluated an MRD-guided course of zanubrutinib, obinutuzumab, and venetoclax (BOVen) in treatment-naïve chronic lymphocytic leukemia, including assessment of zanubrutinib–venetoclax retreatment and…
Fluid choice in pediatric diabetic ketoacidosis: a Systematic Review and Meta-Analysis.
This systematic review and meta-analysis compared balanced electrolyte solutions (BES) with 0.9% saline for fluid resuscitation in children with diabetic ketoacidosis (DKA), including randomized trials and observational…
Multivessel Versus Single-Vessel Coronary Endarterectomy as an Adjunct to Coronary Artery Bypass Grafting: A Meta-Analysis of Short-Term Outcomes and Implications for Target-Vessel Selection.
This meta-analysis compared short-term outcomes after single-vessel versus multivessel coronary endarterectomy (CE) performed with coronary artery bypass grafting (CABG), using studies that reported both groups within…
Catatonic signs during delirium in leptomeningeal melanoma: Treatment trade-offs in end-of-life care.
A man in his late 30s with metastatic melanoma involving the leptomeninges and brain developed fluctuating arousal, inattention, disorientation, mutism, immobility, staring, withdrawal, and waxy flexibility.
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