Angiosarcoma in the Setting of Vascular Procedures: A Systematic Review and Our Experiences.
Phil Yi Jun Lu, Joel Ding, Casey Hiu Ching Fung et al.
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From the abstract
Angiosarcoma is a rare, aggressive endothelial malignancy with a poor prognosis; diagnosis is often delayed by vague symptoms, nonspecific imaging, and challenging histopathology. Case reports have suggested an association with prior vascular procedures, with or without prosthetic material, but no causal link is established.
Reported results
We describe 3 patients with metastatic angiosarcoma contiguous with vascular prostheses: a 75-year-old male with left inguinal angiosarcoma 7 years after PTFE bypass grafting; a 69-year-old male with angiosarcoma within the aneurysm sac 7 years after endovascular aortic aneurysm repair (EVAR); and an 80-year-old male with intraluminal angiosarcoma within an EVAR limb presenting as distal embolization.
Authors' conclusions
Angiosarcoma is difficult to diagnose given its nonspecific presentation but should be considered in atypical or refractory post-procedural presentations. This is the largest synthesis to date and the first to describe intraluminal EVAR-limb angiosarcoma with distal embolization.