Klippel-Trenaunay Syndrome Prenatal Diagnosis: Two Case Reports and a Review of the Literature.
HuiTing Fang, YuJie Li, Jin Zhang et al.
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Case in brief
A report of two fetuses with suspected Klippel-Trenaunay syndrome (KTS) describes prenatal ultrasound findings of marked right-thigh soft-tissue swelling and thickening, with tortuous, dilated arterial and venous channels and abundant Doppler flow. Some veins had a honeycomb-like appearance. After induced abortion, examination showed reddish skin discoloration over the right lower extremity in both fetuses. The diagnosis was based on the concordance between prenatal imaging and gross anatomical findings.
What made this case unusual
The prenatal vascular findings included honeycomb-patterned veins within hypertrophic thigh soft tissue, alongside tortuous, dilated arterial and venous channels.
Diagnostic / clinical pearl
In suspected prenatal KTS, assess for disproportionate soft-tissue and bony overgrowth together with vascular malformations, and distinguish this pattern from other overgrowth syndromes and vascular anomalies.
Why it matters
The authors emphasize that accurate prenatal diagnosis and multidisciplinary perinatal management support pregnancy counseling and assessment of complications that may affect perinatal prognosis.