Bupropion-Induced Aseptic Meningitis: Postmarketing Safety Evaluation and Case Report.
Joseph Cusimano, David Croteau, Jamie Ridley Klucken et al.
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Case in brief
During routine safety surveillance, the FDA identified two cases of aseptic meningitis associated with bupropion. One was sufficiently well documented for the authors to assess the causal association as probable. The abstract does not provide the patient’s presentation, diagnostic findings, or clinical course, so these details cannot be summarized. The safety signal led the FDA to require updates to U.S. prescribing information for bupropion-containing products.
What made this case unusual
The report describes a probable causal association between bupropion and aseptic meningitis, a possible risk identified through postmarketing surveillance despite the drug’s long market presence and widespread use.
Diagnostic / clinical pearl
Consider bupropion as a possible cause of aseptic meningitis; medication-related recognition may help avoid misdiagnosis or hospitalization.