Incidental Thyroid Uptake on 18 F-FES PET/CT Revealing Papillary Thyroid Carcinoma.

Clin Nucl MedSep 11, 2026 (epub)
Case ReportNuclear MedicineRadiology (Diagnostic)Pathology (Anatomic & Clinical)Endocrinology

Pinar Akkus Gunduz, Mahsun Cidemal, Asena Gokcay Canpolat et al.

✦ AI-curated · Sources linked

Case in brief

A 70-year-old woman with endometrial carcinoma underwent 18F-FDG and 18F-FES PET/CT for pretreatment evaluation. Both scans showed focal uptake in a left inferior thyroid nodule. Ultrasound classified it as TI-RADS 3, while fine-needle aspiration showed atypia of undetermined significance. After total thyroidectomy, histopathology identified a 20-mm noninvasive encapsulated classic papillary thyroid carcinoma. ER immunohistochemistry was unavailable, so the relationship between FES uptake and ER expression could not be assessed. She subsequently received 100 mCi of radioactive iodine.

What made this case unusual

The thyroid carcinoma was incidentally detected as focal uptake on both FDG and FES PET/CT; the unavailable ER immunohistochemistry left the significance of FES uptake unresolved.

Diagnostic / clinical pearl

Focal thyroid uptake on PET/CT warrants evaluation even when ultrasound and cytology are not definitive; in this case, histopathology established papillary thyroid carcinoma.

Source

PubMed · PMID 42725470

Published in Clin Nucl Med. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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