Endobronchial Ultrasound-guided Diagnosis of Occult Lung Adenocarcinoma with Normal Chest Radiograph.

Ann Afr MedJul 30, 2026 (epub)
Case ReportPulmonologyOncology (Medical)Radiology (Diagnostic)Nuclear MedicinePathology (Anatomic & Clinical)

Gurrammagari Naga Rohith, V Jereen, D L Sam Bennihin et al.

✦ AI-curated · Sources linked

Case in brief

A 59-year-old woman with cough, hemoptysis, and dyspnea had an unremarkable chest radiograph despite persistent symptoms. HRCT showed abrupt cutoff of the left lower lobe bronchus with distal collapse, suggesting an endobronchial lesion. Bronchoscopy with bronchoalveolar lavage was inconclusive; PET-CT identified a metabolically active left lower lobe mass without nodal involvement. EBUS-guided fine-needle biopsy confirmed adenocarcinoma, with immunohistochemistry positive for TTF-1. The cancer was staged as IIB, and neoadjuvant chemotherapy followed by surgery was planned.

What made this case unusual

The tumor was not apparent on chest radiography; diagnosis followed further imaging and EBUS-guided sampling after conventional bronchoscopy with lavage was inconclusive.

Diagnostic / clinical pearl

A normal chest radiograph does not exclude lung malignancy in a patient with persistent respiratory symptoms; bronchial cutoff and distal collapse on HRCT can prompt further evaluation and tissue sampling.

Source

PubMed · PMID 42533726

Published in Ann Afr Med. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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