Isolated Splenic Tuberculosis in an Immunocompetent Young Woman: A Diagnostic Challenge.

Ann Afr MedJul 7, 2026 (epub)
Case ReportInfectious DiseasesGeneral SurgeryRadiology (Diagnostic)Pathology (Anatomic & Clinical)

Kishor Bhiurao Jeughale, Harish Venketachalam, Dakshayani S Nirhale et al.

✦ AI-curated · Sources linked

Case in brief

A 21-year-old immunocompetent woman presented with vague upper abdominal pain and weight loss, without constitutional symptoms. Examination showed splenomegaly without lymphadenopathy. Contrast-enhanced CT demonstrated multiple rim-enhancing splenic abscesses and areas of infarction; laparoscopy showed multiple pale nodules, leading to splenectomy. Abscess fluid tested negative for TB by GeneXpert, but histopathology confirmed tuberculosis, with caseating granulomas and Langhans giant cells. She received standard antituberculosis therapy for 6 months and had complete resolution on follow-up.

What made this case unusual

The splenic abscess fluid was GeneXpert-negative despite histopathological confirmation of tuberculosis, illustrating a diagnostic pitfall in extrapulmonary disease.

Diagnostic / clinical pearl

A negative GeneXpert result on splenic abscess fluid does not exclude splenic tuberculosis; histopathology may establish the diagnosis.

Source

PubMed · PMID 42411363

Published in Ann Afr Med. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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