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175 articles

November 202613

Clinical ResearchPsychiatry

The Role of Stress-Related Biomarkers, Immune-Inflammatory Pathways, and Genetic Polymorphisms in Cognitive-Behavioral Therapies for Chronic Low Back Pain and Depression: Results From a Randomized Controlled Trial (The IMPACT Study).

This randomized controlled trial examined whether Acceptance and Commitment Therapy (ACT) or Behavioral Activation Therapy for Depression (BATD), each added to usual care, affected biomarkers or clinical outcomes in 114…

Clin J PainNov 11, 2026Read summary
Clinical ResearchRheumatology

Comparative Efficacy of Different Biologic Agents on Radiographic Progression in Patients with Rheumatoid Arthritis: A Network Meta-Analysis.

This Bayesian random-effects network meta-analysis compared six biologic DMARD classes for radiographic progression in rheumatoid arthritis, using randomized controlled trials and change in modified Total Sharp Score…

Arch Immunol Ther Exp (Warsz)Nov 10, 2026Read summary
Clinical ResearchRheumatology

Prevalence of generalized joint hypermobility, hypermobility spectrum disorders and Ehlers-Danlos syndrome: systematic review and meta-analysis.

This systematic review and meta-analysis assessed the prevalence of generalized joint hypermobility (GJH), hypermobility spectrum disorder (HSD) and hypermobile Ehlers-Danlos syndrome (hEDS).

Rheumatol IntNov 5, 2026Read summary
Clinical ResearchRheumatology

Conductive and sensorineural hearing impairment in juvenile idiopathic arthritis: a systematic review and meta-analysis.

This systematic review and meta-analysis assessed middle-ear and cochlear function in children with juvenile idiopathic arthritis (JIA) compared with healthy controls.

Rheumatology (Oxford)Nov 4, 2026Read summary
Clinical ResearchRheumatology

Validity of the 2023 ACR/EULAR APS classification criteria for paediatric primary APS: inputs from a systematic literature review.

This systematic literature review and individual participant data-style random-effects meta-analysis assessed the 2023 ACR/EULAR antiphospholipid syndrome (APS) classification criteria in children with primary APS.

Rheumatology (Oxford)Nov 4, 2026Read summary
Clinical ResearchRheumatology

The effect of exercise program applied to patients with scleroderma on functional outcomes: A randomized controlled trial.

This randomized controlled trial assessed whether an exercise program improved hand and mouth function and quality of life in 46 patients with systemic sclerosis.

Mod RheumatolNov 4, 2026Read summary
Clinical ResearchOrthopedic Surgery

Effects of Exercise Type and Duration on Pain, Function, and Quality of Life in Patients With Knee Osteoarthritis: A Systematic Review With Bayesian Network Meta-Analysis.

This systematic review with Bayesian network meta-analysis compared aerobic, resistance, and combined exercise for pain, function, and quality of life in people with knee osteoarthritis.

J Orthop Sports Phys TherNov 1, 2026Read summary
Clinical ResearchRheumatology

Prevalence of Sleep Disorders in Patients With Knee, Hip, and Hand Osteoarthritis: A Systematic Review With Meta-Analysis.

This prevalence systematic review and meta-analysis assessed insomnia, obstructive sleep apnea, restless legs syndrome, and narcolepsy in people with knee, hip, or hand osteoarthritis.

J Orthop Sports Phys TherNov 1, 2026Read summary
Clinical ResearchRheumatology

ChatGPT and Other Large Language Models in Inflammatory Arthritis: A Systematic Review Across Clinical Tasks.

This systematic review assessed large language model performance across clinical tasks in inflammatory arthritis. It included 18 studies spanning rheumatoid arthritis, axial spondyloarthritis, psoriatic arthritis, gout…

J RheumatolNov 1, 2026Read summary
Clinical ResearchRheumatology

Do People With Tophaceous Gout Require More Allopurinol for Good Clinical Outcomes? Analysis of 2 Randomized Controlled Trials of Allopurinol Dose Escalation.

This analysis of individual participant data from two randomized allopurinol dose-escalation trials compared outcomes in people with gout with and without baseline tophi.

J RheumatolNov 1, 2026Read summary
Clinical ResearchRheumatology

Effect of Bimekizumab Treatment on Health Status, Work Productivity, and Productivity Costs Through 3 Years in Axial Spondyloarthritis and Psoriatic Arthritis.

This analysis assessed health status, work productivity, and productivity-related costs through 3 years among patients with axial spondyloarthritis (axSpA) or psoriatic arthritis (PsA) treated with bimekizumab in phase…

J RheumatolNov 1, 2026Read summary
Clinical ResearchRheumatologyOpen access

Sociodemographic factors, but not rurality, explain limited variance in fibromyalgia severity: a secondary analysis of 2 randomized clinical trials.

This secondary analysis combined baseline data from 685 participants in two randomized clinical trials to examine whether rural residence and sociodemographic characteristics were associated with fibromyalgia severity.

Pain MedNov 1, 2026Read summary
Clinical ResearchRheumatology

Bruton Tyrosine Kinase Inhibitors for Systemic Lupus Erythematosus: A Systematic Review of Randomized Controlled Trials.

This systematic review assessed randomized clinical trials of Bruton tyrosine kinase (BTK) inhibitors for systemic lupus erythematosus (SLE), including potential effects on cutaneous disease.

J Drugs DermatolNov 1, 2026Read summary

October 202611

Clinical ResearchInfectious Diseases

Predictors of chronic arthralgia after chikungunya virus infection: a systematic review and meta-analysis.

This systematic review and meta-analysis examined predictors of chronic arthralgia, defined as lasting at least 3 months, after laboratory-confirmed chikungunya infection.

J Travel MedOct 30, 2026Read summary
Clinical ResearchEndocrinology

Expected change: a new concept for monitoring patients on oral bisphosphonates.

This randomized controlled trial evaluated ways to monitor response to oral bisphosphonates in 108 postmenopausal women younger than 85 years treated with alendronate, ibandronate, or risedronate, with calcium and…

J Bone Miner ResOct 29, 2026Read summary
Clinical ResearchRheumatologyOpen access

Prevalence of depression and anxiety among patients with Behçet's disease: a systematic review and meta-analysis.

This systematic review and random-effects meta-analysis estimated depression and anxiety prevalence among patients with Behçet’s disease (BD).

Adv RheumatolOct 29, 2026Read summary
Clinical ResearchRheumatology

Ianalumab for the Treatment of Patients with Sjögren's Disease.

Two 52-week, double-blind, randomized, placebo-controlled phase III trials evaluated monthly or less frequent ianalumab in patients with active Sjögren's disease.

N Engl J MedOct 22, 2026Read summary
Clinical ResearchOrthopedic SurgeryOpen access

Platelet-rich plasma for knee osteoarthritis: a systematic review and meta-analysis of structural outcomes.

This systematic review and meta-analysis assessed imaging-based structural outcomes after platelet-rich plasma (PRP) treatment in people with knee osteoarthritis.

Arch Orthop Trauma SurgOct 22, 2026Read summary
Clinical ResearchNeurologyOpen access

Determining the minimal important difference of EQ-5D-5 L utility values in CIDP patients using data from a large clinical trial.

This analysis of data from the ADHERE randomized controlled trial estimated the minimal important difference (MID) in EQ-5D-5 L utility values for patients with chronic inflammatory demyelinating polyradiculoneuropathy…

Qual Life ResOct 22, 2026Read summary
Clinical ResearchRheumatology

Calorie-Restricted DASH, Carbohydrate-Restricted, and Low-Purine Diets for Weight Loss and Urate Control in Men With Overweight or Obesity and Hyperuricemia: A Randomized Trial.

This 12-week, open-label, active-comparator randomized trial compared calorie-restricted carbohydrate-restricted, DASH, and low-purine balanced diets in 102 men with overweight or obesity and hyperuricemia.

Diabetes CareOct 21, 2026Read summary
Clinical ResearchRheumatologyOpen access

Association between rheumatic diseases and glaucoma risk: a systematic review and meta-analysis of 5.7 million individuals.

This systematic review and meta-analysis examined glaucoma occurrence and risk among people with rheumatic diseases (RD), drawing on 18 studies with 5,766,143 participants.

Int OphthalmolOct 21, 2026Read summary
Clinical ResearchRheumatologyOpen access

The Effect of Mindfulness-Based Cognitive Therapy on Kinesiophobia in Older Adults with Chronic Knee Osteoarthritis: A Randomized Controlled Trial.

This randomized controlled trial evaluated mindfulness-based cognitive therapy (MBCT) for kinesiophobia in 56 older adults with chronic knee osteoarthritis in Kashan, Iran.

Clin Interv AgingOct 20, 2026Read summary
Clinical ResearchOrthopedic SurgeryOpen access

Systematic review and meta-analysis on comparing treatment approaches of cervical fractures in ankylosing spondylitis to determine improvement in outcomes.

This systematic review and meta-analysis compared anterior, posterior, and combined surgical approaches for cervical fractures in patients with ankylosing spondylitis.

Neurosurg RevOct 17, 2026Read summary
Clinical ResearchMedical Genetics

The extra X chromosome and autoimmune susceptibility in Klinefelter syndrome.

This systematic review and meta-analysis assessed autoimmune susceptibility in people with Klinefelter syndrome (47,XXY), using studies of autoimmune disease and serological markers.

J Clin Endocrinol MetabOct 16, 2026Read summary

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