Prevalence of depression and anxiety among patients with Behçet's disease: a systematic review and meta-analysis.

Adv RheumatolOct 29, 2026 (epub)
Clinical ResearchRheumatologyPsychiatryOpen access

Golbarg Mehrpoor, Mohammad Javad Amini, Arman Shafiee et al.

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In 30 seconds

This systematic review and random-effects meta-analysis estimated depression and anxiety prevalence among patients with Behçet’s disease (BD). Seventeen studies were included; 16 contributed depression data and 11 anxiety data. Pooled prevalence was 47.44% for depression (95% CI: 34.09-60.97%) and 48.48% for anxiety (95% CI: 35.40-61.67%). Both estimates showed substantial heterogeneity (I² > 90%). Depression prevalence differed by assessment instrument, and reported rates varied markedly across geographic regions.

Key findings

  • Pooled depression prevalence was 47.44% (95% CI: 34.09-60.97%) across 16 studies.
  • Pooled anxiety prevalence was 48.48% (95% CI: 35.40-61.67%) across 11 studies.
  • Both pooled estimates had substantial heterogeneity (I² > 90%).
  • Depression prevalence varied by diagnostic instrument; Egypt had the highest reported prevalence for depression (88.83%) and anxiety (92.00%).

Why it matters

The pooled estimates indicate that depression and anxiety are common among people with BD, highlighting psychological morbidity alongside the disease’s physical burden. However, substantial heterogeneity and differences by assessment tool and region mean that prevalence estimates may not apply uniformly across settings. Recognising mental health comorbidity is relevant to comprehensive BD care.

What to keep in mind

Substantial heterogeneity (I² > 90%) limits the consistency and generalisability of the pooled prevalence estimates.

Source

PubMed · PMID 42963807Free full text on PubMed Central

Published in Adv Rheumatol. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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