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1382 articles
October 202624
Ruxolitinib for the treatment of pediatric acute and chronic steroid-refractory graft-versus-host disease: Efficacy, safety, and outcomes.
This single-center retrospective study assessed ruxolitinib in children under 18 years with steroid-refractory graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.
Phase 2 trial to evaluate the safety and immunogenicity of a 25-valent pneumococcal conjugate vaccine (IVT-PCV25) in infants.
This double-blind, randomised phase 2 trial in 421 healthy infants in the Philippines compared three dose-ranging formulations of the 25-valent pneumococcal conjugate vaccine IVT-PCV25 with licensed Prevnar-20.
Molecular characterization of mucolipidosis: A case-series from Iran.
Six unrelated Iranian patients with mucolipidosis underwent molecular characterization. Pathogenic homozygous variants were identified in GNPTAB, GNPTG, and MCOLN1, with all variants classified as pathogenic under ACMG…
Child Neurology: Neonatal Management of Tyrosine Hydroxylase Deficiency: How Early Is Early Enough?
Two preterm neonates from unrelated families with a known family history of tyrosine hydroxylase deficiency were diagnosed early. Both began levodopa/carbidopa treatment during the neonatal period.
Levetiracetam versus valproate for new-onset or previously treated but inadequately controlled epilepsy in children: a systematic review and meta-analysis of randomized controlled trials.
This systematic review and meta-analysis compared levetiracetam with valproate in children aged 0–18 years with new-onset or inadequately controlled epilepsy.
Effectiveness and Influencing Factors of Drama-Based Interventions for Social Skills in Children and Adolescents with Autism Spectrum Disorder: A Meta-Analysis.
This meta-analysis assessed drama-based interventions for social skills in children and adolescents with autism spectrum disorder (ASD), drawing on 16 controlled studies involving 703 participants.
Neurosurgical manifestations and management of mucopolysaccharidoses: A systematic review.
This PRISMA-guided systematic review synthesized contemporary reports of neurosurgical manifestations and management across mucopolysaccharidosis (MPS) subtypes.
Neonatal gastric perforation: a systematic review and meta-analysis of clinical characteristics, risk factors, surgical management and outcomes.
This systematic review and meta-analysis examined clinical features, risk factors, surgical management and outcomes of neonatal gastric perforation using observational studies of neonates aged 28 days or younger.
Ciliated hepatic foregut cyst in children and adolescents: a systematic review of clinical presentation, diagnosis, management, and outcomes.
This PRISMA 2020 systematic review descriptively synthesised case reports and case series of histopathologically confirmed ciliated hepatic foregut cysts in patients aged 19 years or younger.
Phenotypic variability in Arboleda-Tham syndrome: a report of a polish patient with a pathogenic KAT6A variant.
A 6-year-old boy born to healthy parents had global developmental delay, with milestones reached substantially later than expected. Diagnostic evaluation began at 18 months.
The effect of seizure-free period on seizure recurrence following antiseizure medication withdrawal: a systematic review and meta-analysis.
This systematic review and random-effects meta-analysis examined whether the duration of seizure freedom before antiseizure medication (ASM) withdrawal is associated with subsequent seizure recurrence in people with…
Cochlear Implantation in a Child With Arnold-Chiari Syndrome, Severe Inner Ear Malformations, and Cochlear Nerve Hypoplasia: A Case Report.
A 1.5-year-old girl with Arnold-Chiari malformation, hydrocephalus, spina bifida, and profound bilateral sensorineural hearing loss had limited auditory development despite early hearing-aid use.
Oxygen vs Air at Birth for Moderate- to Late-Preterm Infants: The AIROPLANE Cluster Randomized Crossover Trial.
The AIROPLANE trial was an unblinded, cluster randomized crossover study at 26 Australian maternity hospitals comparing initial oxygen concentrations of 0.30 and 0.21 during the first 3 minutes of respiratory support…
The impact of recreational beach tennis associated with nutritional counseling on cardiometabolic risk factors in adolescents: a randomized clinical trial.
This 12-week randomized clinical trial compared recreational beach tennis alone with beach tennis plus nutritional counseling in 40 adolescents aged 11–14 years.
Resistance Exercise for Body Composition in Children Who Are Overweight or Obese.
This systematic review and meta-analysis examined randomized controlled trials of resistance-based exercise in children and adolescents classified as overweight or obese.
FDG PET/CT Unmasking Acute Rheumatic Fever Presenting as Polyenthesitis.
A 13-year-old boy was evaluated with FDG PET/CT for fever of unknown origin. Imaging showed extensive abnormal activity around joints in all four extremities and probable myopericarditis.
A Tale of 3 Tracers: Contrasting Uptake Patterns of 18 F-FDG, 68 Ga-DOTATATE, and 18 F-MFBG in a Pediatric Neuroblastoma Patient.
A 5-year-old boy underwent 18 F-FDG PET/CT before neuroblastoma was confirmed histologically. Imaging showed a metabolically active left adrenal primary tumor and liver metastases.
Unusual Isolated Thymic Relapse of Neuroblastoma Detected By 123 I-mIBG Scintigraphy in a Pediatric Patient.
A pediatric patient with neuroblastoma developed an anterior mediastinal mass representing thymic relapse. The mass showed intense uptake on 123I-meta-iodobenzylguanidine (123I-mIBG) scintigraphy, which detected the…
A Consistently Elevated Pineal Gland Uptake of 18 F-MFBG as a Physiological Normal Variant.
A 3-year-old girl with high-risk neuroblastoma underwent 18F-MFBG PET/CT to assess treatment response. Imaging showed focal pineal gland uptake, also present on concurrent 68Ga-DOTATATE PET/CT.
Detecting Isolated Multifocal Leptomeningeal Metastases With 18F-MFBG PET/CT in a Pediatric Patient With High-risk Neuroblastoma.
A 2-year-old girl with high-risk neuroblastoma had abdominal primary disease and multiple metastases on baseline 18F-MFBG PET/CT. After induction therapy, restaging showed no abnormal tracer uptake.
Mixture of Plasticizer Chemicals and Child Intelligence: A Weight-of-Evidence and Meta-Analysis-Informed Bayesian Approach in a Cohort with Improved Exposure Assessment.
This cohort study examined prenatal and infant exposure to plasticizer chemicals and IQ at age 3 among 380 mother-infant pairs in the French SEPAGES study.
The effects of an online mindfulness-based intervention for parents of children with attention deficit/hyperactivity disorder.
This two-arm randomized controlled trial compared an online mindfulness-based intervention (MBI) with online psychoeducation in 248 parents of children aged 6 to 12 years with ADHD symptoms.
Pacak-Zhuang syndrome with EPAS1 p.Pro531Leu somatic variant: one case report and literature review.
A 4-year-old girl presented with recurrent hypertension, polycythemia and renal hilar masses. Imaging, biochemical testing and genetic analysis of paraffin-embedded tissue confirmed Pacak-Zhuang syndrome with a somatic…
High-Resolution Ultrasound in the Evaluation of Median and Superficial Radial Nerve Involvement in Neurofibromatosis Type 1.
A 16-year-old girl with neurofibromatosis type 1 presented with hand pain and paresthesia. High-resolution ultrasound showed a hypervascular superficial neurofibroma, marked epineural thickening of the median nerve…
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