Detecting Isolated Multifocal Leptomeningeal Metastases With 18F-MFBG PET/CT in a Pediatric Patient With High-risk Neuroblastoma.

Clin Nucl MedOct 20, 2026 (epub)
Case ReportPediatricsOncology (Medical)Nuclear MedicineRadiology (Diagnostic)

Ziqing Shi, Lingling Zheng, Keyu Zhang et al.

✦ AI-curated · Sources linked

Case in brief

A 2-year-old girl with high-risk neuroblastoma had abdominal primary disease and multiple metastases on baseline 18F-MFBG PET/CT. After induction therapy, restaging showed no abnormal tracer uptake. At six-month follow-up, PET/CT demonstrated multifocal 18F-MFBG-avid lesions limited to the cranial compartment, without extracranial recurrence. Contrast-enhanced brain MRI subsequently confirmed leptomeningeal metastases.

What made this case unusual

The multifocal leptomeningeal disease was isolated to the cranial compartment, with no extracranial recurrence, and was detected on 18F-MFBG PET/CT.

Diagnostic / clinical pearl

In this case, cranial-only 18F-MFBG-avid lesions on surveillance PET/CT prompted MRI confirmation of leptomeningeal metastases.

Why it matters

The case illustrates the potential utility of 18F-MFBG PET/CT for detecting central nervous system involvement during surveillance of pediatric neuroblastoma.

Source

PubMed · PMID 42912542

Published in Clin Nucl Med. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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