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2000 articles
September 202624
Extramedullary T-Lymphoblastic Blast Crisis in Chronic Myeloid Leukaemia: A Unique Cytologic Diagnosis Confirmed by Flow Cytometry.
A 40-year-old man presented with generalized lymphadenopathy, hepatosplenomegaly, anemia, and marked leukocytosis. Bone marrow examination indicated chronic phase chronic myeloid leukaemia (CML) with confirmed BCR::ABL1…
Primary Cerebral Pleomorphic-Myxoid Sarcoma With Many Hyaline Globules.
A 59-year-old man presented with a primary sarcoma in the right temporal lobe, following a history of pituitary tumor resection and radiotherapy 40 years prior.
Testicular aggressive B-cell lymphoma with plasmablastic morphology harboring concurrent IGH::MYC and IGH::BCL2 rearrangements.
A 66-year-old immunocompetent man presented with a 5 cm left testicular mass. Histological analysis showed a diffuse proliferation of large atypical lymphoid cells with plasmablastic morphology.
The role of particle therapy in the treatment of locally recurrent rectal cancer: a systematic review.
This systematic review evaluated the role of particle therapy in treating locally recurrent rectal cancer, particularly in patients with unresectable or inoperable cases.
Transcriptomic analysis of a phase 1 trial for intraperitoneal monocytes plus IFNs in ovarian cancer reveals support and recruitment of cell-mediated immunity.
This phase 1 trial investigated the effects of intraperitoneal autologous monocytes with interferons (AMIGA) in women with recurrent, platinum-resistant ovarian cancer.
Chemotherapy with or without pembrolizumab followed by maintenance pembrolizumab with or without olaparib as first-line treatment of patients with advanced BRCA non-mutated epithelial ovarian cancer (ENGOT-OV43/GOG-3036/KEYLYNK-001): a randomised, double-blind, placebo-controlled, phase 3 trial.
This phase 3 randomized trial evaluated the efficacy and safety of pembrolizumab plus chemotherapy followed by pembrolizumab plus olaparib maintenance in 1367 women with advanced BRCA non-mutated epithelial ovarian…
Evidence Gap in Managing Lateral Pelvic Lymph Nodes in Rectal Cancer: a Systematic Review of Radiation Boost Strategies.
This systematic review assessed radiation dose escalation to radiologically suspicious lateral pelvic lymph nodes (LPLNs) during neoadjuvant chemoradiotherapy for locally advanced rectal cancer.
Intravascular large B-cell lymphoma with reversible central hypopituitarism.
A woman in her late 60s presented with fever and general fatigue. Investigations showed bicytopenia, splenomegaly, and central hypothyroidism.
How prevalent is fear of cancer recurrence beyond 5 years: a systematic review of validated assessments across tumour types.
This systematic review examined the prevalence of fear of cancer recurrence (FCR) in survivors beyond 5 years across various tumor types.
Management of oral stomatitis associated with BRAFi-MEKi therapy using intralesional corticosteroid and local anesthetic: a case report.
A 66-year-old woman with a history of choroidal melanoma developed a fibrinopurulent ulcer on the tongue after starting dabrafenib-trametinib therapy for tumor recurrence.
Profiling immune check point inhibitors - Induced arthritis: A systematic review and pooled analyses of cohort studies.
This systematic review and pooled analysis of cohort studies characterized immune checkpoint inhibitor–induced arthritis (ICIs-IA) in patients treated for cancer.
Laparoscopic Resection of Vaginal Cuff Recurrence Following Surgery for Endometrial Cancer.
Vaginal cuff recurrence of endometrial cancer is generally managed with radiotherapy, and surgical reports are scarce. We report a laparoscopic resection technique for isolated vaginal cuff recurrence.
Successful Engraftment Following Second Cord Blood Transplantation After Graft Failure in a Child With Relapsed B-ALL.
A 9-year-old boy with relapsed B-cell precursor acute lymphoblastic leukemia experienced primary graft failure after his first umbilical cord blood transplantation due to low CD34-positive cell dose and significant HLA…
Adult-Onset Langerhans Cell Histiocytosis With Calvarial and Hypothalamic Involvement: Two Cases.
This report details two cases of adult-onset Langerhans cell histiocytosis (LCH). The first case involved a 36-year-old woman with a solitary osteolytic lesion in the calvarium, treated with surgical resection and…
CAR T-cell therapy as a definitive consolidation for older adults with B-ALL in first complete remission.
This phase 1 clinical trial evaluated the safety and efficacy of CD19 CAR T-cell therapy as consolidation treatment in older adults (≥55 years) with B-cell acute lymphoblastic leukemia (B-ALL) in first complete…
Long-term outcomes of azacitidine, venetoclax, and gilteritinib in newly diagnosed FLT3-mutated AML.
This phase II clinical trial evaluated the long-term outcomes of azacitidine, venetoclax, and gilteritinib in 30 adults with newly diagnosed FLT3-mutated acute myeloid leukemia (AML) unfit for intensive chemotherapy.
Induction and consolidation atezolizumab with stereotactic body radiation therapy versus radiation alone in high-risk, early-stage non-small-cell lung cancer (SWOG/NRG S1914): a multicentre, open-label, superiority, phase 3, randomised controlled trial.
This phase 3, multicentre, randomised controlled trial evaluated the addition of atezolizumab to stereotactic body radiation therapy (SBRT) in patients with high-risk, early-stage non-small-cell lung cancer (NSCLC).
Safety and efficacy of allogeneic CD19-directed CAR-T therapy CTX110 in relapsed/refractory B-cell non-Hodgkin lymphoma.
This multicenter, single-arm, phase 1/2 trial assessed the safety and efficacy of CD19-directed CAR-T therapy CTX110 in 63 adults with relapsed/refractory B-cell non-Hodgkin lymphoma.
Primary cutaneous epithelioid hemangioendothelioma of the temporal region: a case report.
A 70-year-old female presented with a progressively ulcerated plaque on her left temple. Histopathological analysis confirmed primary cutaneous epithelioid hemangioendothelioma (EHE) through characteristic features and…
Baricitinib for refractory chronic graft-versus-host disease: results of a phase 1/2 study.
This phase 1/2 study evaluated the safety and efficacy of baricitinib, a JAK 1/2 inhibitor, in 24 adults with refractory chronic graft-versus-host disease (cGVHD) after hematopoietic cell transplantation.
Extraperitoneal Single-Port Robotic-Assisted Radical Cystectomy with Orthotopic Ne-obladder: Technique and Surgical Considerations.
Radical cystectomy (RC) is the standard therapy for muscle-invasive bladder cancer (MIBC) and refractory high-risk non-muscle-invasive bladder cancer (1-3).
Locoregional recurrence of triple-negative breast cancer with low tumor-infiltrating lymphocytes: a case report.
A 49-year-old postmenopausal woman with triple-negative breast cancer (TNBC) experienced an unusual locoregional recurrence three months after a Patey mastectomy.
Safe Accelerated Venetoclax Escalation: a phase 1b study of obinutuzumab plus venetoclax with daily ramp-up in CLL.
This phase 1b clinical trial evaluated the safety and efficacy of an accelerated 5-day inpatient venetoclax ramp-up in 40 patients with chronic lymphocytic leukemia (CLL).
Instruments for measuring body image in breast cancer patients: a systematic review of measurement properties.
This systematic review evaluated the psychometric properties of patient-reported outcome measures (PROMs) for body image in breast cancer patients. Thirty-eight articles assessing fifteen PROMs were included.
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