Testicular aggressive B-cell lymphoma with plasmablastic morphology harboring concurrent IGH::MYC and IGH::BCL2 rearrangements.
Binnari Kim, Hee Jeong Cha
✦ AI-curated · Sources linked
Case in brief
A 66-year-old immunocompetent man presented with a 5 cm left testicular mass. Histological analysis showed a diffuse proliferation of large atypical lymphoid cells with plasmablastic morphology. The tumor exhibited specific immunophenotypic markers and revealed concurrent IGH::MYC and IGH::BCL2 rearrangements. The case underscores the importance of comprehensive diagnostic approaches, integrating morphology and molecular findings.
What made this case unusual
The presence of both IGH::MYC and IGH::BCL2 rearrangements in a testicular aggressive B-cell lymphoma with plasmablastic morphology is particularly rare and presents significant diagnostic challenges.
Diagnostic / clinical pearl
Clinicians should consider the possibility of concurrent IGH::MYC and IGH::BCL2 rearrangements in aggressive B-cell lymphomas with plasmablastic features, especially in immune-privileged sites like the testis.
Why it matters
This case emphasizes the necessity of integrated diagnostic techniques, including morphologic, immunophenotypic, and molecular analyses, to accurately characterize complex lymphomas.