Intravascular large B-cell lymphoma with reversible central hypopituitarism.
Ryuichiro Yamasaki, Masaru Shibata, Kimihisa Awata et al.
✦ AI-curated · Sources linked
Case in brief
A woman in her late 60s presented with fever and general fatigue. Investigations showed bicytopenia, splenomegaly, and central hypothyroidism. Brain MRI indicated enlargement of the anterior pituitary lobe. A skin biopsy revealed atypical lymphocytes in small vessels, confirming intravascular large B-cell lymphoma. The patient achieved complete remission after chemotherapy and stem cell transplantation, with restored endocrine function.
What made this case unusual
This case highlights a rare presentation of intravascular large B-cell lymphoma with hypopituitarism, which is not commonly associated with this type of lymphoma.
Diagnostic / clinical pearl
Clinicians should consider intravascular large B-cell lymphoma in patients presenting with unexplained hypopituitarism and atypical lymphocyte findings.
Why it matters
Recognizing this association can lead to timely diagnosis and treatment, potentially improving patient outcomes in similar cases.