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845 articles
September 202624
Occult Maxillary Sinus Phosphaturic Mesenchymal Tumor Localized by 68 Ga-DOTATATE PET/CT After Repeated Negative Parathyroid Imaging.
A 34-year-old woman had persistent hypophosphatemia and elevated parathyroid hormone levels, prompting repeated evaluation for primary hyperparathyroidism despite negative parathyroid imaging.
[ 18 F]FDG PET/CT Findings of Primary Uterine Dysgerminoma : A Case Report.
A 60-year-old woman presented with dull lower abdominal pain. Ultrasonography showed a posterior uterine mass suspicious for sarcoma.
Glypican-3-Targeted PET/MR Identifies MRI-Indeterminate Early Hepatocellular Carcinoma in Cirrhosis.
A 72-year-old man with hepatitis B-related cirrhosis and rising alpha-fetoprotein had a small hepatic nodule that enlarged across three gadoxetic acid-enhanced MRI examinations over five months but remained…
New Observations on a Low-Grade Diffusely Infiltrative Tumour, SMARCB1 Mutant, Arguing for a New Tumour Type.
This report details two cases of low-grade diffusely infiltrative tumour (LGDIT) in an 18-year-old and a 50-year-old male, both presenting with supratentorial lesions.
Somatostatin Receptor-Expressing Hibernoma Mimicking Malignancy on SSTR-PET in MEN1: A Diagnostic Pitfall.
A 21-year-old woman with MEN1 underwent serial somatostatin receptor (SSTR) PET imaging after curative treatment of pancreatic neoplasia, which was in complete remission.
Astrocyte-Predominant Tau Pathology in a Patient With VCP R191Q Variant.
A Japanese woman with a heterozygous VCP R191Q variant presented with progressive muscle weakness, frontotemporal dementia, and parkinsonism, ultimately passing away at 61.
Circulating tumor DNA and recurrence after curative-intent treatment of hepatocellular carcinoma: A systematic review and meta-analysis.
This systematic review and meta-analysis examined whether circulating tumor DNA (ctDNA) detection predicts outcomes after curative-intent treatment for hepatocellular carcinoma.
Non-ossifying fibroma of the proximal tibia mimicking chronic osteomyelitis in a child.
A teenage boy presented with progressive pain and swelling in the anterior left upper leg, initially suspected to be chronic osteomyelitis.
Peritoneal Desmoplastic Small Round Cell Tumor on FDG PET/CT.
A 21-year-old man presented with intermittent abdominal pain and distension. Contrast-enhanced CT and 18F-FDG PET/CT showed diffuse peritoneal thickening and multiple hypermetabolic masses, prompting concern for…
Surgical outcomes of appendiceal mucinous neoplasms: A systematic review and meta-analysis.
This systematic review and meta-analysis assessed surgical outcomes for appendiceal mucinous neoplasms, drawing on 43 observational cohort studies involving 12,014 patients.
I saw the sign: The black ring sign in carcinoma ex pleomorphic adenoma.
Two patients had carcinoma ex pleomorphic adenoma arising in the left submandibular and left parotid glands. In both tumors, T2-weighted MRI showed a conspicuously thick, hypointense rim around an intratumoral…
When Crystalloids Tell the Story: Amylase Crystalloids in Salivary Gland Cytology.
A 59-year-old female presented with a parotid swelling. Ultrasonography identified a cystic lesion, and fine needle aspiration yielded yellowish fluid.
Molecularly Guided Therapy Versus Continued Chemotherapy in Unfavorable Cancer of Unknown Primary: Updated Efficacy and Safety From the Randomized, Phase II CUPISCO Study.
This updated analysis of the multicenter, randomized phase II CUPISCO trial compared molecularly guided therapy (MGT), selected after comprehensive genomic profiling, with continued platinum-based chemotherapy in…
Metastatic High-Grade Endometrial Stromal Sarcoma With ZC3H7B::BCOR Fusion in Pleural Fluid: A Case Report.
A 32-year-old woman presented with pelvic pain and a large uterine mass considered suspicious for leiomyosarcoma on MRI; imaging also showed pulmonary and vertebral lesions concerning for metastases.
Expanding the Morphologic, Clinical, and Molecular Spectrum of Succinate Dehydrogenase A (SDHA)-Deficient Renal Cell Carcinoma: A Case Series With Review of Literature.
This multi-institutional case series examined five SDHA-deficient renal cell carcinomas (RCCs). Patients had a median age of 40 years, with male predominance.
Unique Thyroid Carcinoma With Somatic Inactivating TSC2 Mutations, Follicular and Melanocytic Differentiation and Distinct Morphologic Features.
Thyroid carcinomas with mutations in the TSC2 gene have been described rarely. Here, we report a unique thyroid carcinoma that has somatic mutations in TSC2 , follicular and melanocytic differentiation and distinct…
Pediatric T-cell lymphoblastic lymphoma with t(9;17)(q34;q23)-associated N-terminally truncated NOTCH1 activation: a case report.
A 6-year-old boy presented with T-cell lymphoblastic lymphoma (T-LBL). Testing identified a t(9;17)(q34;q23) translocation producing a MIR142HG::NOTCH1 fusion and a truncated, constitutively active NOTCH1 protein.
Orbital spindle cell neoplasm with neural differentiation: diagnostic challenges in the absence of molecular confirmation.
An 82-year-old man with previously treated rectal adenocarcinoma developed progressive orbital pain and right-sided proptosis. CT showed an orbital-apex soft-tissue mass without bone erosion.
Early Diagnosis of Upper Eyelid Pyoderma Gangrenosum Using the PARACELSUS Score and Tissue-Sparing Management With Adjunctive Hypochlorous Acid Therapy: A Case Report.
A 17-year-old patient with ulcerative colitis developed progressive upper-eyelid ulceration, initially managed as preseptal cellulitis and later considered a possible necrotizing infection.
Two-Year-Old Girl With Chronic Cough and Lymphadenopathy.
A 27-month-old girl with no significant medical history presented with a chronic cough lasting three months, accompanied by one day of fever and rhinorrhea.
Intratumoral Sotigalimab with Pembrolizumab Induces Rapid Activation of Antigen-Presenting Cells and Drives Antitumor Responses in Non-injected Tumors in Metastatic Melanoma: A Phase I/II Study.
This phase I/II clinical trial evaluated intratumoral sotigalimab, a CD40 agonist, plus pembrolizumab in 32 patients with immune-checkpoint-blocker-naïve metastatic melanoma.
Co-occurrence of pfkelch13 and pfmdr1 variants in a recurrent Plasmodium falciparum infection following standard artemether-lumefantrine treatment.
A patient with metabolic comorbidities developed recurrent Plasmodium falciparum infection after standard artemether-lumefantrine treatment.
Time-varying prognostic value of circulating tumor DNA in urothelial carcinoma: A systematic review and reconstructed patient-data meta-analysis.
This systematic review and reconstructed patient-data meta-analysis assessed the prognostic association of circulating tumor DNA (ctDNA) across non-muscle-invasive, muscle-invasive, upper-tract and metastatic urothelial…
Low-Grade Serous Carcinoma in Association With Endosalpingiosis in a Cervical Lymph Node: A Case Report and Literature Review.
A 41-year-old woman with Horner syndrome had a densely calcified, hypermetabolic supraclavicular lymph node and a remote history of serous borderline tumor with noninvasive implants.
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