Low-Grade Serous Carcinoma in Association With Endosalpingiosis in a Cervical Lymph Node: A Case Report and Literature Review.

Diagn CytopatholSep 1, 2026 (epub)
Case ReportPathology (Anatomic & Clinical)Oncology (Medical)Radiology (Diagnostic)

Nyein Nyein Htun, Nour Sneige

✦ AI-curated · Sources linked

Case in brief

A 41-year-old woman with Horner syndrome had a densely calcified, hypermetabolic supraclavicular lymph node and a remote history of serous borderline tumor with noninvasive implants. Fine-needle aspiration and core biopsy showed tubal-type epithelium consistent with endosalpingiosis beside a micropapillary and cribriform neoplastic proliferation with psammoma bodies. PAX-8, estrogen receptor, and WT1 staining supported Müllerian origin. PET-CT showed no recurrent pelvic disease. Neck dissection confirmed low-grade serous carcinoma arising in association with nodal endosalpingiosis.

What made this case unusual

The carcinoma arose in a cervical lymph node alongside benign endosalpingiosis, an unusual setting for malignant transformation; imaging showed dense calcification and hypermetabolism.

Diagnostic / clinical pearl

In a cervical node, tubal-type epithelium adjacent to a Müllerian-pattern neoplasm should prompt consideration of endosalpingiosis-associated low-grade serous carcinoma, rather than assuming a conventional metastatic carcinoma.

Source

PubMed · PMID 42681975

Published in Diagn Cytopathol. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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