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2000 articles
November 202624
Zanubrutinib, obinutuzumab, and venetoclax in CLL: long-term follow up, MRD kinetics, retreatment, T-cell profiling, and PKs.
This phase 2 trial evaluated an MRD-guided course of zanubrutinib, obinutuzumab, and venetoclax (BOVen) in treatment-naïve chronic lymphocytic leukemia, including assessment of zanubrutinib–venetoclax retreatment and…
Duodenal Adenocarcinoma Recurrence Limited to the Choledochojejunostomy After Pancreaticoduodenectomy: A Case Suggesting Intraluminal Implantation With a Distinct Mucin Phenotypic Shift.
A 59-year-old man developed recurrence at the choledochojejunostomy 27 months after pancreaticoduodenectomy for duodenal adenocarcinoma, despite five surgically created raw surfaces.
Concomitant Robotic Pericardial Window and Mediastinal Tumour Biopsy Under Intraoperative Ultrasound Guidance.
An 83-year-old woman presented with an undiagnosed mediastinal mass and a symptomatic, loculated pericardial effusion. She underwent a robotic pericardial window and mediastinal tumour biopsy performed together under…
Rare Sites of Metastases to the Breast and Integumentary System in Advanced Cervical Cancer at Initial Presentation in Eastern Uganda: A Case Report.
A 72-year-old woman in Uganda presented after 13 months of intermittent postmenopausal bleeding and abnormal vaginal discharge, despite repeated treatment for presumed urinary and sexually transmitted infections.
Artificial Urinary Sphincter in Women: A Systematic Review of Clinical Outcomes and Technological Evolutions.
This systematic review examined clinical outcomes, surgical approaches, quality of life, and device developments for artificial urinary sphincter (AUS) implantation in women with stress urinary incontinence related to…
Metagenomic Next-Generation Sequencing of Mycoplasma hominis Infection in an Immunocompromised Patient: A Case Report.
A 52-year-old immunocompromised man developed persistent soft-tissue infection after a wooden splinter injury, with recurrent fever, wound pain, swelling, and exudation.
Klippel-Trenaunay Syndrome Prenatal Diagnosis: Two Case Reports and a Review of the Literature.
A report of two fetuses with suspected Klippel-Trenaunay syndrome (KTS) describes prenatal ultrasound findings of marked right-thigh soft-tissue swelling and thickening, with tortuous, dilated arterial and venous…
A Case of Facial Alternaria alternata Infection in an Immunocompetent Male with Albinism.
A 26-year-old immunocompetent man with albinism who worked in breeding presented with a two-month history of itchy facial rashes.
Fluid choice in pediatric diabetic ketoacidosis: a Systematic Review and Meta-Analysis.
This systematic review and meta-analysis compared balanced electrolyte solutions (BES) with 0.9% saline for fluid resuscitation in children with diabetic ketoacidosis (DKA), including randomized trials and observational…
Predictive Accuracy and Procedural Benefits of Software-Enhanced Flow-Diverter Planning: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed whether software simulations improve flow-diverter (FD) planning and procedural outcomes for intracranial aneurysms compared with physician planning.
Comparative Effectiveness of Non-Pharmacological Interventions for Management of Post-Orthodontic Pain: A Systematic Review and Network Meta-Analysis.
This systematic review and Bayesian network meta-analysis compared nine non-pharmacological approaches for orthodontic pain after fixed-appliance activation.
Digital Outreach to Improve Statin Refills in Patients With Low Statin Adherence: The ADHERE-ASCVD Randomized Clinical Trial.
The ADHERE-ASCVD pragmatic, health system-embedded randomized clinical trial tested adaptive digital outreach to prompt statin refills among adults with established ASCVD or high ASCVD risk and recent nonadherence.
Addition of probenecid to beta-lactam antibiotics in the treatment of skin and soft tissue infections: a systematic review.
This systematic review assessed the effectiveness and safety of adding probenecid to beta-lactam antibiotics for skin and soft tissue infections (SSTIs).
Singing-based interventions for motor and non-motor symptoms in Parkinson's disease: a systematic review.
This systematic review examined interventional studies of singing-based rehabilitation for motor and non-motor symptoms in people with Parkinson’s disease.
Network-Based Deep Brain Stimulation Rescue After Magnetic Resonance-Guided Focused Ultrasound Thalamotomy for Essential Tremor: Two Targeting Strategies.
Two men developed recurrent essential tremor after MRgFUS thalamotomy. In the 71-year-old, DBS was placed along a Vim–posterior subthalamic area trajectory.
Effects of exercise interventions on leptin and ghrelin levels in middle-aged and older adults with overweight or obesity: a systematic review and meta-analysis.
This systematic review and meta-analysis assessed randomized controlled trials of exercise interventions in middle-aged and older adults with overweight or obesity, examining changes in leptin and ghrelin.
Pain, sensory acceptability, and treatment compliance following cryotherapy and topical anesthetics in children: A randomized clinical trial.
This randomized clinical trial compared cryotherapy with topical anesthetics in 100 healthy children aged 7–10 years receiving their first dental treatment.
Homozygous SCA8 presenting as severe axonal neuropathy without overt cerebellar involvement.
A 35-year-old man with progressive limb weakness beginning at age 15 had severe proximal muscle atrophy and absent deep tendon reflexes, without overt cerebellar signs.
Anterior Chest Wall Tuberculosis Masquerading as a Chronic Parasternal Sinus in an Apparently Immunocompetent Adult: A Diagnostic Challenge in a Resource-Limited Setting.
A previously healthy 22-year-old man presented with an enlarging parasternal-xiphoid swelling and intermittent seropurulent drainage, without respiratory or constitutional symptoms.
Multivessel Versus Single-Vessel Coronary Endarterectomy as an Adjunct to Coronary Artery Bypass Grafting: A Meta-Analysis of Short-Term Outcomes and Implications for Target-Vessel Selection.
This meta-analysis compared short-term outcomes after single-vessel versus multivessel coronary endarterectomy (CE) performed with coronary artery bypass grafting (CABG), using studies that reported both groups within…
Oncologic efficacy and safety of stereotactic body radiotherapy for oligometastatic non-small cell lung cancer: a systemic meta-analysis.
This systematic review and meta-analysis assessed the efficacy and safety of stereotactic body radiotherapy (SBRT) for oligometastatic non-small cell lung cancer, including analyses by oligometastatic subtype and…
Tegmental Heterotopia in PHACE Syndrome: A Previously Undescribed Feature.
The report describes two infants with PHACE syndrome and infratentorial neuroglial heterotopia involving the tectal plate. A 6-week-old infant with a right segmental facial hemangioma and ventricular septal defect had…
Epidemiological, etiological, and antifungal resistance patterns of vulvovaginal Candida spp. infections in Cameroon: A systematic review and meta-analysis.
This systematic review and meta-analysis pooled evidence from 34 studies of vulvovaginal Candida infection and vulvovaginal candidiasis (VVC) in Cameroon.
Acquired haemophilia B in Kyasanur Forest disease: a case series of isolated prolonged activated partial thromboplastin time.
Nine patients with confirmed acute Kyasanur Forest disease had prolonged activated partial thromboplastin time (APTT) with normal prothrombin time.
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