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2000 articles
November 202616
Effects of Integrated Multicomponent Care on Older Adults With Frailty or Pre-Frailty: A Systematic Review and Meta-Analysis.
This systematic review and meta-analysis assessed integrated multicomponent care (IMC) for older adults with frailty or pre-frailty, including evidence from 20 randomised and quasi-experimental studies.
Pump-Predicted Ciprofol Ce50 for Suppressing the Cardiovascular Response to Tracheal Intubation During Fixed Sufentanil-Esketamine Induction: An Age-Stratified Dixon Up-and-Down Study.
To estimate the ciprofol pump-predicted effect-site target concentration associated with a 50% probability of suppressing the cardiovascular response to tracheal intubation (Ce50) during fixed sufentanil-esketamine…
Paxalisib with Trastuzumab for HER2-Positive Metastatic Breast Cancer with Active Brain Metastases: A Phase II Trial with Integrated Plasma and CSF ctDNA Analyses.
This phase II trial evaluated brain-penetrant paxalisib plus trastuzumab in patients with active or progressive HER2-positive breast cancer brain metastases, including heavily pretreated patients; leptomeningeal disease…
Impact of Aspirin Use on Mortality and Cardiac Allograft Vasculopathy After Heart Transplantation: A Systematic Review and Meta-analysis.
This systematic review and meta-analysis examined whether aspirin use was associated with mortality and cardiac allograft vasculopathy (CAV)-related outcomes in heart transplant recipients.
A comparison of the efficacy and safety of direct oral anticoagulants with low molecular weight heparin for venous thromboembolism prophylaxis after total hip arthroplasty : a systematic review and meta-analysis.
This systematic review and meta-analysis compared direct oral anticoagulants (DOACs) with low molecular weight heparin (LMWH) for venous thromboembolism prophylaxis after elective total hip arthroplasty.
Can Clinicians Predict Which Patients Respond Best to a Specific Treatment? A Systematic Review of Low Back Pain Moderators in Primary Care.
This systematic review synthesized randomized trials and secondary analyses examining whether patient characteristics modify responses to primary care interventions for nonspecific low back pain.
Eltrombopag during induction chemotherapy in older patients with newly diagnosed acute myeloid leukemia is safe and reduces platelet transfusion requirements: The EPAG-2015 French Innovative Leukemia Organization phase 2 randomized trial.
The multicentre, phase 2 randomized trial EPAG-2015 evaluated eltrombopag started after induction chemotherapy in patients aged 60 years or older with newly diagnosed acute myeloid leukemia.
A Moisturizer With Centella asiatica and Mandelic Acid Reduces Bruising and Speeds Recovery in Mature Skin.
This 12-week multicenter, randomized, blinded, in-use study evaluated a moisturizer containing Centella asiatica and mandelic acid in men and women aged 40 to 60 years with fragile, bruise-prone skin.
Digital reminder systems for improving adherence to anti-rabies vaccination among animal bite victims: A systematic review.
This systematic review assessed whether digital reminders improve adherence to and completion of anti-rabies vaccination among animal-bite patients.
From Shrapnel to Stability: A Reverse Perforator Flap for Definitive Elbow Coverage Seven Decades Post-Trauma. A Case Report.
A man injured by shrapnel at age four sustained a severe right elbow fracture and complete ulnar nerve transection, leaving ankylosis and chronic dysfunction.
Pediatric Liver Transplantation Following Donation After Circulatory Death Using Normothermic Regional Perfusion: A Novel Application.
A 15-year-old girl with fulminant hepatic failure after acetaminophen overdose underwent liver transplantation using a donation-after-circulatory-death graft recovered with thoracoabdominal normothermic regional…
Effect of Food on the Pharmacokinetics, Pharmacodynamics, and Safety of Zastaprazan, a Potassium-Competitive Acid Blocker, in Healthy Participants.
This randomized, open-label, two-period crossover phase 1 study assessed food effects on zastaprazan pharmacokinetics, pharmacodynamics, and safety in 24 healthy participants given a single 20 mg dose.
Compositional, Spatial and Functional Changes Occur Within Bacteria Associated With Precancerous Colonic Lesions: A Systematic Review.
This systematic review examined human studies comparing gut microbiota in people with colorectal polyps and healthy controls defined by normal colonoscopy.
Brain Abscesses as a Complication of Brain Hematomas in Infective Endocarditis: A Rare Case Report.
A previously healthy 26-year-old man with methicillin-sensitive Staphylococcus aureus infective endocarditis had a 24-mm parietal hematoma; angiography showed no aneurysm.
Toxoplasma gondii in Ethiopia: A Systematic Review and Meta-Analysis of Infection Prevalence and Associated Risk Factors in Humans and Animals.
This systematic review and random-effects meta-analysis estimated Toxoplasma gondii prevalence and associated risk factors in humans and ruminants in Ethiopia, using studies published between 2012 and 2025.
Six-Month Music Practice Versus Psychomotor Interventions in Mild Cognitive Impairment: Behavioral and Hippocampal Outcomes.
This pilot randomized controlled intervention study compared six months of intensive musical instrument training with psychomotor interventions in people with mild cognitive impairment (MCI), using matched healthy…
October 20268
Glucose and insulin responses to monk fruit-based sweetener formulations and their effects on appetite, liking and wanting, and energy intake (GREEN): a randomized double-blind, crossover study.
This randomized, double-blind, crossover study compared three monk fruit-based sweetener formulations (MF1–MF3) with sucrose and sucralose in 30 healthy adults.
Closed reduction in distal radius fractures: manual manipulation vs. finger trap traction-a prospective randomized controlled clinical trial.
This prospective, single-centre, 1:1 randomized controlled trial compared finger-trap traction (FTT) with additional manual reduction (MR) under haematoma block in 53 patients with acute distal radius fractures (AO…
Solitary Neurofibroma in the Submental Region of a 15-Year-Old Adolescent: A Case Report and Review of Literature.
A 15-year-old boy had a painless right submental swelling present for one year, with enlargement over the preceding three months.
Evaluation of surgical outcomes and costs during the learning curve in robotic gynecologic surgery: a systematic review and meta-analysis.
This systematic review and meta-analysis examined whether surgical outcomes and costs differed between earlier and later cases of the same robotic gynecologic procedures.
Early functional deterioration during first-line ICI-based therapy in advanced NSCLC: implications for supportive care.
This secondary exploratory analysis of prospectively collected data from a randomized pulmonary rehabilitation trial assessed early functional change in 42 people receiving first-line immune checkpoint inhibitor–based…
Breathing Exercises as Adjunct Therapy in Adult Asthma: A Systematic Review.
This systematic review assessed breathing retraining as an adjunct to pharmacological treatment in adults with asthma. It included 15 studies involving 1,786 participants: 12 randomised trials, one quasi-randomised…
Effect of electroconvulsive therapy on anhedonia in adults with major depressive disorder: A systematic review and meta-analysis.
This systematic review and meta-analysis examined changes in anhedonia among adults with major depressive disorder treated with electroconvulsive therapy (ECT).
Impacts of Oliceridine versus Sufentanil on the Quality of Postoperative Recovery in Elective Gynecological Laparoscopic Surgery: A Randomized Controlled Trial.
This single-centre randomized controlled trial compared patient-controlled intravenous analgesia with oliceridine or sufentanil in 136 women aged 18–65 years undergoing elective laparoscopic gynecological surgery.
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