Occult Abdominal Para-Aortic Ectopic Insulinoma Localized by 18 F-NOTA-Exendin-4 PET/CT.

Clin Nucl MedOct 20, 2026 (epub)
Case ReportEndocrinologyNuclear MedicineRadiology (Diagnostic)

Yan Wan, Hao Wang, Lijuan Feng et al.

✦ AI-curated · Sources linked

Case in brief

A 68-year-old woman with a 10-year history of recurrent hypoglycemic syncope had confirmed endogenous hyperinsulinemia. Conventional imaging and laparoscopic exploration of the pancreas did not identify a lesion. 18 F-NOTA-exendin-4 PET/CT showed an intense solitary focus in the para-aortic abdominal region. Surgical resection confirmed an ectopic insulinoma, and the hypoglycemia resolved postoperatively.

What made this case unusual

The insulinoma was solitary and ectopic, with no concurrent pancreatic or gastrointestinal lesion, and remained occult on conventional imaging and pancreatic exploration.

Diagnostic / clinical pearl

In this case, 18 F-NOTA-exendin-4 PET/CT localized an ectopic insulinoma after conventional imaging and pancreatic exploration were unrevealing.

Source

PubMed · PMID 42912647

Published in Clin Nucl Med. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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