Tubulointerstitial Nephritis With Uveitis (TINU) Syndrome: A Case Series and Review of Literature.
Weaam Ali, Nidhi Agrawal, Smeeta Sinha et al.
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Case in brief
A case series of ten patients diagnosed with Tubulointerstitial Nephritis with Uveitis (TINU) syndrome revealed that renal disease often preceded uveitis, with 60% of cases showing this pattern. At presentation, 70% had elevated serum creatinine levels, and all renal biopsies confirmed tubulointerstitial nephritis. Treatment with corticosteroids was effective, but 60% experienced renal relapses, particularly during steroid tapering. At a median follow-up of 44 months, half of the patients had chronic kidney disease.
What made this case unusual
This cohort included a broader age range (15-67 years) than typically reported, with a notable adult predominance, and demonstrated a high relapse rate of 60% during steroid tapering.
Diagnostic / clinical pearl
Clinicians should be aware that TINU syndrome can present with renal symptoms prior to uveitis, and both conditions may not occur simultaneously, complicating diagnosis.
Why it matters
The findings highlight the importance of monitoring renal function and proteinuria in patients with TINU syndrome, as early intervention may mitigate the risk of chronic kidney disease.