Diagnostic Usefulness of Cell Block Samples in Fluid Overload-Associated Large B-Cell Lymphoma.

Diagn CytopatholAug 11, 2026 (epub)
Case ReportPathology (Anatomic & Clinical)Hematology

Hiroyuki Okanishi, Hiroko Kuwabara, Hiroko Nakayama et al.

✦ AI-curated · Sources linked

Case in brief

An 81-year-old woman presented with pericardial and pleural effusions and was diagnosed with stage IVA fluid overload-associated large B-cell lymphoma (FO-LBCL), despite having no underlying condition that could explain fluid overload. Cytology from both effusions showed atypical medium- to large-sized lymphoid cells. Immunohistochemistry on the pleural-fluid cell block showed CD20 and CD79a positivity, with negative CD3, KSHV/HHV-8, and Epstein-Barr virus; the Ki-67 labeling index was 95%. After systemic chemotherapy, she achieved complete remission, with no pleural or pericardial recurrence during 3-year follow-up.

What made this case unusual

The patient had FO-LBCL with serous effusions despite no underlying medical condition that could lead to fluid overload.

Diagnostic / clinical pearl

In suspected FO-LBCL, cell-block immunohistochemistry can help confirm the diagnosis from effusion cytology and inform therapy selection, alongside clinical and imaging findings.

Source

PubMed · PMID 42576650

Published in Diagn Cytopathol. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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