Heart Failure in Young Women with Systemic Lupus Erythematosus.

Ann Afr MedJul 23, 2026 (epub)
Case ReportCardiologyRheumatologyNephrology

Vijayashree Gokhale, Divam Prakash Singh, Sangram Mangudkar et al.

✦ AI-curated · Sources linked

Case in brief

Two women aged 23 and 36 years with newly diagnosed systemic lupus erythematosus presented with acute decompensated heart failure, dyspnea, edema, and cardiomegaly. Findings included nephrotic-range proteinuria, acute kidney injury, strongly positive ANA blot, and NT-proBNP >35,000 pg/mL. Echocardiography showed biventricular dysfunction, with initial LVEF of 20%-35%, alongside significant tricuspid regurgitation and pulmonary arterial hypertension. Lupus myocarditis and nephritis were diagnosed. Both received immunosuppressive and heart-failure therapies; the fulminant case also underwent plasma exchange. After cyclophosphamide, LVEF recovered to 50%-55% within 1-2 months, renal function improved, and heart-failure symptoms resolved.

What made this case unusual

Severe biventricular dysfunction from lupus myocarditis occurred concurrently with lupus nephritis in both young women, yet cardiac function substantially recovered after treatment.

Diagnostic / clinical pearl

In newly diagnosed SLE with acute heart failure, concurrent renal involvement and biventricular dysfunction should prompt consideration of lupus myocarditis; echocardiography can document severity and recovery.

Source

PubMed · PMID 42487361

Published in Ann Afr Med. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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