Testosterone Dysregulation and Erectile Dysfunction Associated With Teprotumumab Infusions: A Case Report.

Ophthalmic Plast Reconstr SurgJul 20, 2026 (epub)
Case ReportEndocrinologyOphthalmology

Sri Meghana Konda, Lisa Y Lin, Suzanne K Freitag

✦ AI-curated · Sources linked

Case in brief

A 52-year-old man receiving teprotumumab for active thyroid eye disease developed erectile dysfunction, low libido, and low testosterone during treatment. Testosterone levels and symptoms normalized after the first course. With recurrent eye disease, the same pattern returned during a second course; testosterone replacement improved symptoms and levels, which again normalized after treatment ended. Erectile dysfunction and low testosterone recurred one week after the second dose of a third course, and testosterone replacement again improved his hypogonadal symptoms and levels.

What made this case unusual

The testosterone dysregulation and erectile dysfunction recurred during each of three teprotumumab courses, with testosterone levels normalizing after the first two courses ended.

Diagnostic / clinical pearl

In this case, erectile dysfunction and low testosterone emerged during teprotumumab treatment and recurred with subsequent courses; assessing testosterone may help characterize new hypogonadal symptoms during therapy.

Source

PubMed · PMID 42475232

Published in Ophthalmic Plast Reconstr Surg. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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AI-generated summaries may contain errors or omissions. Verify clinically important information with the original publication.

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