Primary salivary gland neuroendocrine carcinoma with multidisciplinary insights.

Int J Oral Maxillofac SurgJun 18, 2026 (epub)
Case ReportOncology (Medical)Otolaryngology (ENT)Pathology (Anatomic & Clinical)Nuclear MedicineRadiology (Diagnostic)

Y Han, Y Zhang, X Zhang et al.

✦ AI-curated · Sources linked

Case in brief

A 68-year-old man was diagnosed with primary large cell neuroendocrine carcinoma of the parotid. PET-CT showed two hypermetabolic nodules confined to the gland, with no distant metastasis. Histopathology and immunohistochemical profiling confirmed high-grade neuroendocrine carcinoma, with a Ki-67 index >40%. He underwent total parotidectomy with immediate facial nerve grafting, followed by adjuvant chemoradiotherapy. No recurrence or metastasis was observed at 4-month follow-up.

What made this case unusual

Primary parotid LCNEC is exceptionally uncommon; the report notes fewer than 30 cases. Imaging identified two hypermetabolic nodules confined to the gland.

Diagnostic / clinical pearl

Diagnosis in this case relied on integrating PET-CT findings with histopathology and immunohistochemical profiling to identify primary parotid LCNEC and assess for distant disease.

Source

PubMed · PMID 42315429

Published in Int J Oral Maxillofac Surg. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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