The Diagnostic Utility of PRAME in a Case of Trans-Differentiated Melanoma Metastatic to the Heart.

Int J Surg PatholJun 9, 2026 (epub)
Case ReportPathology (Anatomic & Clinical)Oncology (Medical)Cardiology

Carla Stephan, Jose Jessurun

✦ AI-curated · Sources linked

Case in brief

A patient had metastatic melanoma involving the left atrium. The tumor had lost melanocytic differentiation and acquired rhabdomyosarcomatous differentiation, making its diagnosis challenging because melanocytic markers were negative. Immunohistochemistry showed diffuse, strong PRAME positivity, which supported recognition of the tumor as metastatic melanoma despite the divergent phenotype.

What made this case unusual

The cardiac metastasis showed trans-differentiation to a rhabdomyosarcomatous phenotype alongside loss of melanocytic markers, while retaining diffuse, strong PRAME staining.

Diagnostic / clinical pearl

When a suspected melanoma metastasis lacks melanocytic marker expression and shows divergent differentiation, PRAME immunohistochemistry may provide useful diagnostic support.

Source

PubMed · PMID 42261696

Published in Int J Surg Pathol. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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