Subretinal fluid resolution in the fellow eye after unilateral aflibercept injection in bilateral neovascular age-related macular degeneration: Coincidence or systemic effect?

Arch Soc Esp Oftalmol (Engl Ed)May 25, 2026 (epub)
Case ReportOphthalmologyRadiology (Diagnostic)

R Demirel, S Gültekin Irgat, H I Bike

✦ AI-curated · Sources linked

Case in brief

A 63-year-old woman with bilateral neovascular age-related macular degeneration (nAMD) developed new subretinal fluid (SRF) in her left eye, which had best-corrected visual acuity of 0.8, while receiving treat-and-extend aflibercept therapy in the right eye. To avoid injection-related risks in the better-seeing eye, clinicians treated only the right eye. Three weeks later, optical coherence tomography showed complete resolution of left-eye SRF. The fluid remained absent for 8 weeks before recurring.

What made this case unusual

SRF resolved in the untreated fellow eye after unilateral aflibercept injection, then recurred. The observation raises the possibility of a temporary systemic anti-VEGF effect on fellow-eye choroidal neovascularisation activity.

Diagnostic / clinical pearl

After unilateral anti-VEGF treatment, fellow-eye SRF may resolve temporarily; this single case cannot establish a systemic treatment effect or guide clinical practice.

Source

PubMed · PMID 42190944

Published in Arch Soc Esp Oftalmol (Engl Ed). This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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