Acute stress alters prefrontal resting-state networks and tES restores functional connectivity.

J Affect DisordMay 15, 2026 (epub)
Clinical ResearchPsychiatryNeurology

Zhihua Guo, Yue Gong, Rui Qiu et al.

✦ AI-curated · Sources linked

In 30 seconds

This randomized controlled trial examined the effects of acute stress on prefrontal resting-state connectivity in 196 healthy male undergraduates. Results indicated that acute stress altered connectivity patterns, while pre-stress transcranial electrical stimulation (tES) effectively restored functional connectivity, particularly with tACS showing broader effects compared to tDCS.

Key findings

  • Acute stress suppressed adaptive interhemispheric connectivity and reduced left DLPFC centrality.
  • Pre-stress tES, especially tACS, counteracted stress-induced connectivity alterations.
  • tACS demonstrated more widespread effects across the prefrontal cortex than tDCS.

Why it matters

Understanding how acute stress impacts brain connectivity is crucial for developing interventions. The potential of tES, particularly tACS, to mitigate these effects may inform future strategies for managing stress-related disorders.

Source

PubMed · PMID 42142754

Published in J Affect Disord. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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