Serial assessment of NT-proBNP and high-sensitivity cardiac troponin with glucagon-like peptide-1 receptor agonist therapy in type 2 diabetes: Insights from EXSCEL.

Am Heart JMay 6, 2026 (epub)
Clinical ResearchCardiologyEndocrinology

Veraprapas Kittipibul, Maggie Nguyen, Paul Welsh et al.

✦ AI-curated · Sources linked

In 30 seconds

This randomized controlled trial from the EXSCEL study evaluated the prognostic value of NT-proBNP and high-sensitivity cardiac troponin I in 4,292 adults with type 2 diabetes receiving exenatide or placebo. It found that baseline NT-proBNP was a strong predictor of major adverse cardiovascular events (MACE) and mortality, with a hazard ratio of 1.63 for MACE per 1 unit increase.

Key findings

  • Baseline NT-proBNP was prognostic for MACE (HR 1.63), all-cause mortality (HR 1.85), CV death (HR 2.17), and hHF (HR 2.17).
  • A 1-year increase in NT-proBNP predicted later MACE (HR 1.85) and CV death (HR 2.81).
  • Higher baseline cTnI concentrations were associated with lower rates of CV deaths and hHF with exenatide.

Why it matters

Understanding the prognostic value of cardiac biomarkers like NT-proBNP and cTnI can help clinicians better assess cardiovascular risk in patients with type 2 diabetes, potentially guiding treatment decisions and monitoring.

Source

PubMed · PMID 42102896

Published in Am Heart J. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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