The effect of low-carbohydrate diets on serum concentration of soluble adhesion molecules: a systematic review and meta-analysis of randomized controlled trials.

Int J Environ Health ResApr 21, 2026 (epub)
Clinical ResearchCardiologyEndocrinology

Mahdieh Khodarahmi, Sanaz Mehrabani, Gholamreza Askari

✦ AI-curated · Sources linked

In 30 seconds

This systematic review and meta-analysis evaluated the impact of low-carbohydrate diets (LCDs) on serum levels of adhesion molecules in adults. Analyzing data from nine randomized controlled trials with 333 participants, the study found that LCDs significantly reduced E-selectin concentrations by 3.95 ng/mL compared to controls (95% CI: -6.42 to -1.47; P = 0.002).

Key findings

  • LCDs significantly reduced E-selectin concentrations by 3.95 ng/mL compared to control groups.
  • No significant effects were observed on ICAM, VCAM, or P-selectin levels.
  • The analysis included nine publications with a total of 333 participants.
  • No heterogeneity was found in the results (I² = 0.0%).

Why it matters

Understanding the effects of dietary interventions on adhesion molecules is crucial, as they play a role in cardiovascular disease. This research suggests that LCDs may offer a beneficial effect on E-selectin levels, potentially influencing cardiovascular health.

What to keep in mind

Given limited studies and dietary heterogeneity, findings should be interpreted cautiously.

Source

PubMed · PMID 42015424

Published in Int J Environ Health Res. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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