Health-Related Quality of Life in People Living with HIV andHypertension: Effects of a Short Message Service-Based Mobile HealthIntervention (MOPHADHIV Trial).
Danleen James Hongoro, Andre Pascal Kengne, Nasheeta Peer et al.
✦ AI-curated · Sources linked
In 30 seconds
This analysis of the MOPHADHIV 12-month randomized controlled trial assessed health-related quality of life (HRQoL) in people living with HIV and hypertension at four community health centres in Cape Town, South Africa. Among 582 participants with complete baseline and 12-month data, the SMS-based intervention did not improve HRQoL. At 12 months, EQ-5D-5L utility was higher in the control group than the intervention group (0.97 vs 0.95; mean difference 0.03; p = 0.01), a small effect. Visual analogue scale scores improved in both groups without significant between-group differences.
Key findings
- At 12 months, EQ-5D-5L utility was 0.97 vs 0.95 in control and intervention groups, respectively (mean difference 0.03; p = 0.01; Cohen's d = 0.22).
- Adjusted analyses associated intervention allocation with lower EQ-5D-5L utility (fully adjusted β = - 0.03, p < 0.01).
- Visual analogue scale scores improved in both groups, with no significant between-group difference.
Why it matters
The findings suggest that an SMS intervention intended to support self-management does not necessarily translate into better measured HRQoL for people living with HIV and hypertension. The difference in utility was small, and baseline HRQoL was already high. The authors also note that EQ-5D-5L may not capture psychosocial aspects of HIV-related quality of life, which is relevant when interpreting patient-reported outcomes.
What to keep in mind
The analysis included only participants with complete HRQoL data at baseline and 12 months. High baseline HRQoL and the limited sensitivity of EQ-5D-5L to HIV-related psychosocial domains may have constrained detection of change.