Peliosis Hepatis Induced by Tamoxifen Therapy in a Patient with Breast Cancer.
Eriko Narusawa, Shohei Kodama, Takashi Hoshino et al.
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Case in brief
A woman in her 50s receiving multimodal treatment for breast cancer, including tamoxifen, was found on imaging to have a 3-cm hepatic lesion one year after surgery. Tumor marker levels were mostly normal. Biopsy showed blood-filled cavities without fibrosis; CD34 staining suggested collapsed sinusoidal structures, supporting a diagnosis of peliosis hepatis. After tamoxifen was discontinued, the lesion gradually decreased in size.
What made this case unusual
The hepatic lesion was diagnosed as peliosis hepatis by biopsy, with CD34 staining suggesting collapsed sinusoidal structures, and decreased after tamoxifen discontinuation.
Diagnostic / clinical pearl
In a patient taking tamoxifen, a hepatic lesion may represent peliosis hepatis; biopsy findings of blood-filled cavities without fibrosis can support the diagnosis.
Why it matters
The report identifies tamoxifen-associated peliosis hepatis as a consideration in the differential diagnosis of hepatic lesions.