Ophthalmic Rosai-Dorfman Disease and the Revised Classification of Histiocytoses: A Case Series and Review of the Literature.
Adam G de la Garza, Sarinee Juntipwong, Morgan L McLemore et al.
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Case in brief
At one academic institution, a 10-year review identified 48 patients with Rosai-Dorfman disease (RDD); 12 had ophthalmic findings. Their presentations included cutaneous, nodal, and extranodal forms. The authors also reviewed published ophthalmic RDD reports and categorized the institutional and published cases using the revised 2016 histiocytosis classification. The report describes the range of orbital and ocular involvement but does not provide individual diagnostic work-ups or outcomes.
What made this case unusual
The institutional series highlights the varied ophthalmic presentations of RDD and applies the revised 2016 histiocytosis classification to both local cases and published reports.
Diagnostic / clinical pearl
Ophthalmic RDD can involve the orbit and ocular structures, and diagnosis remains challenging; the authors note that better pre-biopsy diagnostic accuracy is needed.