Mediterranean Diet Reduces Inflammation in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Nutr RevSep 1, 2026
Clinical ResearchCardiologyEndocrinologyInternal Medicine (General)

Mahdi Keshani, Sahar Rafiee, Hajar Heidari et al.

✦ AI-curated · Sources linked

In 30 seconds

This systematic review and meta-analysis evaluated the impact of the Mediterranean diet (MD) on inflammation and oxidative stress biomarkers in 3,476 adults across 33 randomized controlled trials. The MD significantly reduced high-sensitivity C-reactive protein (hs-CRP), interleukin (IL)-6, and IL-17 compared to control diets, indicating its potential in mitigating inflammation-related risks.

Key findings

  • The MD significantly reduced hs-CRP, IL-6, and IL-17 compared to control diets.
  • No significant effects were observed for CRP, IL-10, tumor necrosis factor-alpha, or total antioxidant capacity.
  • Stronger effects on IL-6 were noted in participants aged <60 years and with intervention durations <12 weeks.

Why it matters

Understanding the effects of dietary patterns like the Mediterranean diet on inflammation can guide clinicians in recommending lifestyle modifications to reduce chronic disease risks, particularly in patients with cardiovascular conditions.

Source

PubMed · PMID 41211687

Published in Nutr Rev. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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