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Important medical research and remarkable case reports worth knowing.

Selected from high-relevance medical literature published in the last 14 days.

AllClinical ResearchCase Reports
FeaturedClinical ResearchInfectious Diseases

Predictors of chronic arthralgia after chikungunya virus infection: a systematic review and meta-analysis.

J Travel MedOct 30, 2026

This systematic review and meta-analysis examined predictors of chronic arthralgia, defined as lasting at least 3 months, after laboratory-confirmed chikungunya infection.

Why it matters

The findings suggest that persistent post-chikungunya joint symptoms may be more consistently associated with identifiable baseline host characteristics than with a uniform pattern of acute illness severity.

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Also worth knowing

Clinical ResearchPsychiatry

The Role of Stress-Related Biomarkers, Immune-Inflammatory Pathways, and Genetic Polymorphisms in Cognitive-Behavioral Therapies for Chronic Low Back Pain and Depression: Results From a Randomized Controlled Trial (The IMPACT Study).

This randomized controlled trial examined whether Acceptance and Commitment Therapy (ACT) or Behavioral Activation Therapy for Depression (BATD), each added to usual care, affected biomarkers or clinical outcomes in 114…

Clin J PainNov 11, 2026Read summary
Clinical ResearchOrthopedic Surgery

Effects of Exercise Type and Duration on Pain, Function, and Quality of Life in Patients With Knee Osteoarthritis: A Systematic Review With Bayesian Network Meta-Analysis.

This systematic review with Bayesian network meta-analysis compared aerobic, resistance, and combined exercise for pain, function, and quality of life in people with knee osteoarthritis.

J Orthop Sports Phys TherNov 1, 2026Read summary
Clinical ResearchRheumatology

Comparative Efficacy of Different Biologic Agents on Radiographic Progression in Patients with Rheumatoid Arthritis: A Network Meta-Analysis.

This Bayesian random-effects network meta-analysis compared six biologic DMARD classes for radiographic progression in rheumatoid arthritis, using randomized controlled trials and change in modified Total Sharp Score…

Arch Immunol Ther Exp (Warsz)Nov 10, 2026Read summary
Clinical ResearchRheumatology

The effect of exercise program applied to patients with scleroderma on functional outcomes: A randomized controlled trial.

This randomized controlled trial assessed whether an exercise program improved hand and mouth function and quality of life in 46 patients with systemic sclerosis.

Mod RheumatolNov 4, 2026Read summary
Clinical ResearchRheumatology

Validity of the 2023 ACR/EULAR APS classification criteria for paediatric primary APS: inputs from a systematic literature review.

This systematic literature review and individual participant data-style random-effects meta-analysis assessed the 2023 ACR/EULAR antiphospholipid syndrome (APS) classification criteria in children with primary APS.

Rheumatology (Oxford)Nov 4, 2026Read summary
Clinical ResearchRheumatology

Conductive and sensorineural hearing impairment in juvenile idiopathic arthritis: a systematic review and meta-analysis.

This systematic review and meta-analysis assessed middle-ear and cochlear function in children with juvenile idiopathic arthritis (JIA) compared with healthy controls.

Rheumatology (Oxford)Nov 4, 2026Read summary
Clinical ResearchRheumatology

Prevalence of generalized joint hypermobility, hypermobility spectrum disorders and Ehlers-Danlos syndrome: systematic review and meta-analysis.

This systematic review and meta-analysis assessed the prevalence of generalized joint hypermobility (GJH), hypermobility spectrum disorder (HSD) and hypermobile Ehlers-Danlos syndrome (hEDS).

Rheumatol IntNov 5, 2026Read summary
Clinical ResearchRheumatology

Effect of Bimekizumab Treatment on Health Status, Work Productivity, and Productivity Costs Through 3 Years in Axial Spondyloarthritis and Psoriatic Arthritis.

This analysis assessed health status, work productivity, and productivity-related costs through 3 years among patients with axial spondyloarthritis (axSpA) or psoriatic arthritis (PsA) treated with bimekizumab in phase…

J RheumatolNov 1, 2026Read summary
Clinical ResearchRheumatologyOpen access

Sociodemographic factors, but not rurality, explain limited variance in fibromyalgia severity: a secondary analysis of 2 randomized clinical trials.

This secondary analysis combined baseline data from 685 participants in two randomized clinical trials to examine whether rural residence and sociodemographic characteristics were associated with fibromyalgia severity.

Pain MedNov 1, 2026Read summary
Clinical ResearchRheumatology

Do People With Tophaceous Gout Require More Allopurinol for Good Clinical Outcomes? Analysis of 2 Randomized Controlled Trials of Allopurinol Dose Escalation.

This analysis of individual participant data from two randomized allopurinol dose-escalation trials compared outcomes in people with gout with and without baseline tophi.

J RheumatolNov 1, 2026Read summary
Clinical ResearchRheumatology

Prevalence of Sleep Disorders in Patients With Knee, Hip, and Hand Osteoarthritis: A Systematic Review With Meta-Analysis.

This prevalence systematic review and meta-analysis assessed insomnia, obstructive sleep apnea, restless legs syndrome, and narcolepsy in people with knee, hip, or hand osteoarthritis.

J Orthop Sports Phys TherNov 1, 2026Read summary

Showing 12 of 14 publications that cleared our clinical screen in the last 14 days.

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